BRD-K85606544_neratinib_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K85606544_neratinib_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
C4BPA complement component 4 binding protein, alpha
CP ceruloplasmin (ferroxidase)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GADD45B growth arrest and DNA-damage-inducible, beta
HOMER2 homer scaffolding protein 2
HP haptoglobin
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTA1 metastasis associated 1
NT5DC2 5'-nucleotidase domain containing 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PID1 phosphotyrosine interaction domain containing 1
PTPRO protein tyrosine phosphatase, receptor type, O
RHOB ras homolog family member B
S100A10 S100 calcium binding protein A10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPTSSA serine palmitoyltransferase, small subunit A

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANXA3 annexin A3
AREG amphiregulin
CD24 CD24 molecule
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP5 dual specificity phosphatase 5
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
ISL1 ISL LIM homeobox 1
MAP7 microtubule-associated protein 7
MGP matrix Gla protein
OLFM4 olfactomedin 4
S100A7 S100 calcium binding protein A7
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS1 tensin 1