BRD-K85402309_dovitinib_BT20_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K85402309_dovitinib_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ASMTL acetylserotonin O-methyltransferase-like
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPM carboxypeptidase M
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
ESR1 estrogen receptor 1
GREB1 growth regulation by estrogen in breast cancer 1
HMG20B high mobility group 20B
IGHM immunoglobulin heavy constant mu
KIAA1033 KIAA1033
LAMP5 lysosomal-associated membrane protein family, member 5
NAV2 neuron navigator 2
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
SCGB2A1 secretoglobin, family 2A, member 1
SFRP1 secreted frizzled-related protein 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
XPO7 exportin 7

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BIK BCL2-interacting killer (apoptosis-inducing)
CBR3 carbonyl reductase 3
CCNE2 cyclin E2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEMIP cell migration inducing protein, hyaluronan binding
CLCA2 chloride channel accessory 2
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CRISP3 cysteine-rich secretory protein 3
CSTA cystatin A (stefin A)
CTSK cathepsin K
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
FAP fibroblast activation protein, alpha
FLNB filamin B, beta
FOXC1 forkhead box C1
JAG1 jagged 1
KRT6A keratin 6A, type II
MAL mal, T-cell differentiation protein
MARCKSL1 MARCKS-like 1
MGP matrix Gla protein
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NQO1 NAD(P)H dehydrogenase, quinone 1
PERP PERP, TP53 apoptosis effector
PGAM1 phosphoglycerate mutase 1 (brain)
PI3 peptidase inhibitor 3, skin-derived
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTBP3 polypyrimidine tract binding protein 3
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS1 thrombospondin 1
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSPAN1 tetraspanin 1