BRD-K84924563_6-diazo-5-oxo-l-norleucine_NCIH508_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

192 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_NCIH508_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ASPN asporin
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
FBLN1 fibulin 1
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FN1 fibronectin 1
FST follistatin
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
INHBA inhibin, beta A
KIAA1462 KIAA1462
LGALS8 lectin, galactoside-binding, soluble, 8
LUM lumican
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS2 Meis homeobox 2
MFSD10 major facilitator superfamily domain containing 10
MPPED2 metallophosphoesterase domain containing 2
MTMR9 myotubularin related protein 9
MZB1 marginal zone B and B1 cell-specific protein
NCAM1 neural cell adhesion molecule 1
NRCAM neuronal cell adhesion molecule
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE8B phosphodiesterase 8B
PDLIM3 PDZ and LIM domain 3
PDZRN3 PDZ domain containing ring finger 3
PERP PERP, TP53 apoptosis effector
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RHOBTB1 Rho-related BTB domain containing 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX17 SRY (sex determining region Y)-box 17
SPON2 spondin 2, extracellular matrix protein
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRO trophinin
UBE3B ubiquitin protein ligase E3B
VIM vimentin
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP10B ATPase, class V, type 10B
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BAG1 BCL2-associated athanogene
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
C21ORF33 chromosome 21 open reading frame 33
C8ORF33 chromosome 8 open reading frame 33
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CD59 CD59 molecule, complement regulatory protein
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHPT1 choline phosphotransferase 1
CLDN3 claudin 3
CLN5 ceroid-lipofuscinosis, neuronal 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
CSK c-src tyrosine kinase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYTL1 cytokine-like 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EBP emopamil binding protein (sterol isomerase)
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
FAM134B family with sequence similarity 134, member B
FAM13A family with sequence similarity 13, member A
FHL2 four and a half LIM domains 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GTF3A general transcription factor IIIA
GTPBP8 GTP-binding protein 8 (putative)
HN1 hematological and neurological expressed 1
HOXB6 homeobox B6
HOXB7 homeobox B7
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
KPNB1 karyopherin (importin) beta 1
LAMB3 laminin, beta 3
LARP1 La ribonucleoprotein domain family, member 1
LRP10 low density lipoprotein receptor-related protein 10
LTF lactotransferrin
LY75 lymphocyte antigen 75
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLEC malectin
MMP7 matrix metallopeptidase 7
MOAP1 modulator of apoptosis 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDHX pyruvate dehydrogenase complex, component X
PDZD8 PDZ domain containing 8
PIP prolactin-induced protein
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB40B RAB40B, member RAS oncogene family
RBM3 RNA binding motif (RNP1, RRM) protein 3
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPIA ribose 5-phosphate isomerase A
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
S100A2 S100 calcium binding protein A2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SEH1L SEH1-like (S. cerevisiae)
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPRB signal recognition particle receptor, B subunit
STK39 serine threonine kinase 39
SYNGR2 synaptogyrin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN12 tetraspanin 12
TSPAN3 tetraspanin 3
TSPAN31 tetraspanin 31
TSPAN8 tetraspanin 8
TSTA3 tissue specific transplantation antigen P35B
UBE4A ubiquitination factor E4A
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
XK X-linked Kx blood group
ZNHIT6 zinc finger, HIT-type containing 6