BRD-K84924563_6-diazo-5-oxo-l-norleucine_MDST8_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_MDST8_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASS1 argininosuccinate synthase 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BLNK B-cell linker
CA2 carbonic anhydrase II
CALML3 calmodulin-like 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CCND2 cyclin D2
CD200 CD200 molecule
CD24 CD24 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL8A2 collagen, type VIII, alpha 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DENND1B DENN/MADD domain containing 1B
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
FBLN1 fibulin 1
FHOD3 formin homology 2 domain containing 3
FNBP1L formin binding protein 1-like
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDO1 indoleamine 2,3-dioxygenase 1
IGHM immunoglobulin heavy constant mu
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITM2C integral membrane protein 2C
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
JUP junction plakoglobin
KRT19 keratin 19, type I
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
MYOF myoferlin
MZB1 marginal zone B and B1 cell-specific protein
NQO2 NAD(P)H dehydrogenase, quinone 2
P3H2 prolyl 3-hydroxylase 2
PBX1 pre-B-cell leukemia homeobox 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCI protein kinase C, iota
PTPRK protein tyrosine phosphatase, receptor type, K
PXDN peroxidasin
RAB25 RAB25, member RAS oncogene family
RAI14 retinoic acid induced 14
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SHB Src homology 2 domain containing adaptor protein B
SLAMF7 SLAM family member 7
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SOX13 SRY (sex determining region Y)-box 13
SPARCL1 SPARC-like 1 (hevin)
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST18 suppression of tumorigenicity 18, zinc finger
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TNS3 tensin 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF415 zinc finger protein 415
ZNF586 zinc finger protein 586
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACAT1 acetyl-CoA acetyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ALCAM activated leukocyte cell adhesion molecule
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AQP9 aquaporin 9
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
F2R coagulation factor II (thrombin) receptor
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FKBP10 FK506 binding protein 10, 65 kDa
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
FPGS folylpolyglutamate synthase
GANAB glucosidase, alpha; neutral AB
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
LAMP1 lysosomal-associated membrane protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP3 latent transforming growth factor beta binding protein 3
MAMLD1 mastermind-like domain containing 1
NPC2 Niemann-Pick disease, type C2
NPM3 nucleophosmin/nucleoplasmin 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
PLSCR3 phospholipid scramblase 3
PLTP phospholipid transfer protein
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PRPF19 pre-mRNA processing factor 19
PRR7 proline rich 7 (synaptic)
PTMA prothymosin, alpha
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
SACS sacsin molecular chaperone
SLC35F2 solute carrier family 35, member F2
SORBS3 sorbin and SH3 domain containing 3
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TUBA1A tubulin, alpha 1a
UBE2S ubiquitin-conjugating enzyme E2S
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
WBSCR22 Williams Beuren syndrome chromosome region 22