BRD-K84924563_6-diazo-5-oxo-l-norleucine_HEPG2_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_HEPG2_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BMP4 bone morphogenetic protein 4
CA2 carbonic anhydrase II
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CD24 CD24 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CKAP4 cytoskeleton-associated protein 4
CLIC4 chloride intracellular channel 4
COPS7A COP9 signalosome subunit 7A
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EXT1 exostosin glycosyltransferase 1
FKBP4 FK506 binding protein 4, 59kDa
FOLR1 folate receptor 1 (adult)
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
HIST1H2BG histone cluster 1, H2bg
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI16 interferon, gamma-inducible protein 16
IGHM immunoglobulin heavy constant mu
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LTF lactotransferrin
MAMLD1 mastermind-like domain containing 1
MAP7 microtubule-associated protein 7
MN1 meningioma (disrupted in balanced translocation) 1
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
OPN3 opsin 3
ORC1 origin recognition complex, subunit 1
OSBPL10 oxysterol binding protein-like 10
PEG10 paternally expressed 10
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SDC1 syndecan 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOCS1 suppressor of cytokine signaling 1
SOX11 SRY (sex determining region Y)-box 11
TARP TCR gamma alternate reading frame protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACTA2 actin, alpha 2, smooth muscle, aorta
AGR2 anterior gradient 2
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BEX1 brain expressed, X-linked 1
C8ORF4 chromosome 8 open reading frame 4
CFH complement factor H
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CXCL8 chemokine (C-X-C motif) ligand 8
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCGBP Fc fragment of IgG binding protein
GAS7 growth arrest-specific 7
GJA1 gap junction protein, alpha 1, 43kDa
GSTM3 glutathione S-transferase mu 3 (brain)
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HN1 hematological and neurological expressed 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOMER1 homer scaffolding protein 1
ITGB4 integrin, beta 4
KDM5D lysine (K)-specific demethylase 5D
LGALS1 lectin, galactoside-binding, soluble, 1
LRP4 low density lipoprotein receptor-related protein 4
MMD monocyte to macrophage differentiation-associated
MYBPC1 myosin binding protein C, slow type
NPY neuropeptide Y
OXTR oxytocin receptor
PF4 platelet factor 4
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOM stomatin
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM100 transmembrane protein 100
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
ZBTB38 zinc finger and BTB domain containing 38