BRD-K84924563_6-diazo-5-oxo-l-norleucine_HCC15_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_HCC15_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ALB albumin
APOA1 apolipoprotein A-I
APOB apolipoprotein B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DENND1B DENN/MADD domain containing 1B
DLK1 delta-like 1 homolog (Drosophila)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FABP6 fatty acid binding protein 6, ileal
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
GAGE3 G antigen 3
GNAS GNAS complex locus
GP2 glycoprotein 2 (zymogen granule membrane)
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
KCTD14 potassium channel tetramerization domain containing 14
KRT23 keratin 23, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MEIS1 Meis homeobox 1
MMP7 matrix metallopeptidase 7
MPZL2 myelin protein zero-like 2
NID1 nidogen 1
NIT1 nitrilase 1
OSBPL10 oxysterol binding protein-like 10
PALMD palmdelphin
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLN phospholamban
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RBM15B RNA binding motif protein 15B
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIRPA signal-regulatory protein alpha
TACSTD2 tumor-associated calcium signal transducer 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AK4 adenylate kinase 4
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
BET1 Bet1 golgi vesicular membrane trafficking protein
BTN3A2 butyrophilin, subfamily 3, member A2
C6ORF48 chromosome 6 open reading frame 48
CD59 CD59 molecule, complement regulatory protein
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
GOLT1B golgi transport 1B
HDGFRP3 hepatoma-derived growth factor, related protein 3
IGFBP7 insulin-like growth factor binding protein 7
LDHB lactate dehydrogenase B
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MRPS30 mitochondrial ribosomal protein S30
NPC2 Niemann-Pick disease, type C2
RDX radixin
RGS1 regulator of G-protein signaling 1
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SKP1 S-phase kinase-associated protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TMEM47 transmembrane protein 47
TSPAN3 tetraspanin 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGCG UDP-glucose ceramide glucosyltransferase
XPO7 exportin 7
ZBTB38 zinc finger and BTB domain containing 38