BRD-K84924563_6-diazo-5-oxo-l-norleucine_DV90_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_DV90_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AFF1 AF4/FMR2 family, member 1
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
C6ORF62 chromosome 6 open reading frame 62
C8ORF4 chromosome 8 open reading frame 4
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCND2 cyclin D2
CELF2 CUGBP, Elav-like family member 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKLF chemokine-like factor
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ECD ecdysoneless homolog (Drosophila)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ENOPH1 enolase-phosphatase 1
FABP4 fatty acid binding protein 4, adipocyte
FKBP11 FK506 binding protein 11, 19 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ICAM1 intercellular adhesion molecule 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
LBH limb bud and heart development
LXN latexin
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
MFAP4 microfibrillar-associated protein 4
NPY1R neuropeptide Y receptor Y1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAC8 placenta-specific 8
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RND3 Rho family GTPase 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SVIL supervillin
TARP TCR gamma alternate reading frame protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TDO2 tryptophan 2,3-dioxygenase
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TRAM1 translocation associated membrane protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE3B ubiquitin protein ligase E3B
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASRGL1 asparaginase like 1
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BIN1 bridging integrator 1
BSG basigin (Ok blood group)
CA12 carbonic anhydrase XII
CERS6 ceramide synthase 6
CLPTM1 cleft lip and palate associated transmembrane protein 1
COL18A1 collagen, type XVIII, alpha 1
COL9A3 collagen, type IX, alpha 3
CREB3L1 cAMP responsive element binding protein 3-like 1
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F5 coagulation factor V (proaccelerin, labile factor)
FAM69A family with sequence similarity 69, member A
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
G6PD glucose-6-phosphate dehydrogenase
GPI glucose-6-phosphate isomerase
GSTP1 glutathione S-transferase pi 1
HMGA1 high mobility group AT-hook 1
HPCAL1 hippocalcin-like 1
HSPB1 heat shock 27kDa protein 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM4B lysine (K)-specific demethylase 4B
KLK11 kallikrein-related peptidase 11
LTF lactotransferrin
LYZ lysozyme
MFAP5 microfibrillar associated protein 5
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYRF myelin regulatory factor
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
OPHN1 oligophrenin 1
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM1 PDZ and LIM domain 1
PFKL phosphofructokinase, liver
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PLEC plectin
PNKP polynucleotide kinase 3'-phosphatase
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKCSH protein kinase C substrate 80K-H
PTX3 pentraxin 3, long
RPL37A ribosomal protein L37a
SDC2 syndecan 2
SF3A2 splicing factor 3a, subunit 2, 66kDa
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STXBP2 syntaxin binding protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIM28 tripartite motif containing 28
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZFP36L2 ZFP36 ring finger protein-like 2