BRD-K84924563_6-diazo-5-oxo-l-norleucine_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K84924563_6-diazo-5-oxo-l-norleucine_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
CA2 carbonic anhydrase II
CDK14 cyclin-dependent kinase 14
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CLCA4 chloride channel accessory 4
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CXCR4 chemokine (C-X-C motif) receptor 4
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPP4 dipeptidyl-peptidase 4
EXT1 exostosin glycosyltransferase 1
FKBP4 FK506 binding protein 4, 59kDa
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
GJA1 gap junction protein, alpha 1, 43kDa
GRB7 growth factor receptor-bound protein 7
HSPA4 heat shock 70kDa protein 4
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
MAP7 microtubule-associated protein 7
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MSMB microseminoprotein, beta-
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLIN2 perilipin 2
PRUNE2 prune homolog 2 (Drosophila)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS5 regulator of G-protein signaling 5
RIPK4 receptor-interacting serine-threonine kinase 4
RNASE6 ribonuclease, RNase A family, k6
RTN2 reticulon 2
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
CD99 CD99 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
FAM46A family with sequence similarity 46, member A
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
LIPG lipase, endothelial
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
S100A11 S100 calcium binding protein A11
S100A2 S100 calcium binding protein A2
SET SET nuclear proto-oncogene
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TPGS2 tubulin polyglutamylase complex subunit 2
TXNIP thioredoxin interacting protein
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon