BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AREG amphiregulin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
CDC25B cell division cycle 25B
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CES1 carboxylesterase 1
CPM carboxypeptidase M
CYTH1 cytohesin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP6 dual specificity phosphatase 6
ELF1 E74-like factor 1 (ets domain transcription factor)
EMP1 epithelial membrane protein 1
EREG epiregulin
FOXF1 forkhead box F1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GPER1 G protein-coupled estrogen receptor 1
H1F0 H1 histone family, member 0
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KRT5 keratin 5, type II
KYNU kynureninase
MAP7 microtubule-associated protein 7
MSMB microseminoprotein, beta-
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
RAP1GAP RAP1 GTPase activating protein
S100P S100 calcium binding protein P
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SORD sorbitol dehydrogenase
SPRR3 small proline-rich protein 3
STC2 stanniocalcin 2
TBX3 T-box 3
TDP2 tyrosyl-DNA phosphodiesterase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
CD24 CD24 molecule
CDK14 cyclin-dependent kinase 14
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
DUSP22 dual specificity phosphatase 22
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBL fibrillarin
FGFR1 fibroblast growth factor receptor 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FSTL1 follistatin-like 1
IFITM1 interferon induced transmembrane protein 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100505650 uncharacterized LOC100505650
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
OSBPL10 oxysterol binding protein-like 10
PDZK1IP1 PDZK1 interacting protein 1
PSPH phosphoserine phosphatase
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SPON1 spondin 1, extracellular matrix protein
TFPI2 tissue factor pathway inhibitor 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
XIST X inactive specific transcript (non-protein coding)