BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

49 genes differentially expressed following the BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CA12 carbonic anhydrase XII
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CYFIP2 cytoplasmic FMR1 interacting protein 2
GOLGA8A golgin A8 family, member A
HOOK2 hook microtubule-tethering protein 2
LPL lipoprotein lipase
NEFL neurofilament, light polypeptide
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TKT transketolase
TLE4 transducin-like enhancer of split 4
TNIK TRAF2 and NCK interacting kinase
TRIP6 thyroid hormone receptor interactor 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ALB albumin
ASS1 argininosuccinate synthase 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD40 CD40 molecule, TNF receptor superfamily member 5
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
FABP1 fatty acid binding protein 1, liver
FST follistatin
GC group-specific component (vitamin D binding protein)
IFI16 interferon, gamma-inducible protein 16
KRT23 keratin 23, type I
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
MECOM MDS1 and EVI1 complex locus
MXRA5 matrix-remodelling associated 5
NT5E 5'-nucleotidase, ecto (CD73)
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8
ZFP36L2 ZFP36 ring finger protein-like 2