BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-K84881516_Thiophene-2-carboxylic acid benzothiazol-2-ylamide MLS-0446110.0001_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
BACE2 beta-site APP-cleaving enzyme 2
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CCL4 chemokine (C-C motif) ligand 4
CD200 CD200 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CLC Charcot-Leyden crystal galectin
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ELANE elastase, neutrophil expressed
EXT1 exostosin glycosyltransferase 1
FXYD3 FXYD domain containing ion transport regulator 3
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
LAMP1 lysosomal-associated membrane protein 1
LRMP lymphoid-restricted membrane protein
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLVAP plasmalemma vesicle associated protein
POU2AF1 POU class 2 associating factor 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB25 RAB25, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOCS2 suppressor of cytokine signaling 2
SUSD4 sushi domain containing 4
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRG6 adhesion G protein-coupled receptor G6
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
ANXA5 annexin A5
AREG amphiregulin
ARMCX2 armadillo repeat containing, X-linked 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BICC1 BicC family RNA binding protein 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNB1 cyclin B1
CCNB2 cyclin B2
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CHMP4A charged multivesicular body protein 4A
CLIC5 chloride intracellular channel 5
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
ECT2 epithelial cell transforming 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETNK1 ethanolamine kinase 1
FABP4 fatty acid binding protein 4, adipocyte
FKBP3 FK506 binding protein 3, 25kDa
GBAS glioblastoma amplified sequence
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GLS glutaminase
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GOLT1B golgi transport 1B
GSPT2 G1 to S phase transition 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB11 heat shock protein family B (small), member 11
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL18 interleukin 18
ITGB5 integrin, beta 5
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KLHDC2 kelch domain containing 2
KRT14 keratin 14, type I
LACTB2 lactamase, beta 2
LPAR1 lysophosphatidic acid receptor 1
LUM lumican
LXN latexin
LY75 lymphocyte antigen 75
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NNT nicotinamide nucleotide transhydrogenase
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OAT ornithine aminotransferase
OSBPL9 oxysterol binding protein-like 9
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PEG10 paternally expressed 10
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB4 phospholipase C, beta 4
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLS3 plastin 3
PNMAL1 paraneoplastic Ma antigen family-like 1
PPA1 pyrophosphatase (inorganic) 1
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD1 RAD1 checkpoint DNA exonuclease
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RECQL RecQ helicase-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RRP1B ribosomal RNA processing 1B
S100A11 S100 calcium binding protein A11
SACS sacsin molecular chaperone
SERBP1 SERPINE1 mRNA binding protein 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMNDC1 survival motor neuron domain containing 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOAT1 sterol O-acyltransferase 1
SRSF11 serine/arginine-rich splicing factor 11
STRN3 striatin, calmodulin binding protein 3
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SYNM synemin, intermediate filament protein
TFAM transcription factor A, mitochondrial
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM165 transmembrane protein 165
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TXNDC9 thioredoxin domain containing 9
USP1 ubiquitin specific peptidase 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF131 zinc finger protein 131