BRD-K84677391_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K84677391_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY7 adenylate cyclase 7
C2CD2 C2 calcium-dependent domain containing 2
CDK6 cyclin-dependent kinase 6
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHMP4A charged multivesicular body protein 4A
COL15A1 collagen, type XV, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1A1 casein kinase 1, alpha 1
CTSH cathepsin H
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNM1L dynamin 1-like
DUSP10 dual specificity phosphatase 10
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FXYD3 FXYD domain containing ion transport regulator 3
FYB FYN binding protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GTF2A2 general transcription factor IIA, 2, 12kDa
IQCG IQ motif containing G
ITM2A integral membrane protein 2A
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MGLL monoglyceride lipase
NKX3-1 NK3 homeobox 1
NPY neuropeptide Y
PENK proenkephalin
PPARG peroxisome proliferator-activated receptor gamma
PRKCB protein kinase C, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SMS spermine synthase
SRSF7 serine/arginine-rich splicing factor 7
TACSTD2 tumor-associated calcium signal transducer 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPPP3 tubulin polymerization-promoting protein family member 3
TRBC1 T cell receptor beta constant 1
TRH thyrotropin-releasing hormone
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UBE2A ubiquitin-conjugating enzyme E2A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AEBP1 AE binding protein 1
AQP1 aquaporin 1 (Colton blood group)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CBS cystathionine-beta-synthase
CDC20 cell division cycle 20
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CTGF connective tissue growth factor
DPYSL3 dihydropyrimidinase-like 3
FABP7 fatty acid binding protein 7, brain
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT18 keratin 18, type I
LAMA4 laminin, alpha 4
LOX lysyl oxidase
MFAP5 microfibrillar associated protein 5
NNMT nicotinamide N-methyltransferase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFRL platelet-derived growth factor receptor-like
PLK1 polo-like kinase 1
PTPRO protein tyrosine phosphatase, receptor type, O
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RPL37A ribosomal protein L37a
RRAGD Ras-related GTP binding D
SATB1 SATB homeobox 1
SDC2 syndecan 2
SGCE sarcoglycan, epsilon
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SNX7 sorting nexin 7
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
XIST X inactive specific transcript (non-protein coding)