BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD9 CD9 molecule
CLIC4 chloride intracellular channel 4
CPB1 carboxypeptidase B1 (tissue)
DIDO1 death inducer-obliterator 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F11R F11 receptor
FAM49A family with sequence similarity 49, member A
FHL1 four and a half LIM domains 1
FXYD6 FXYD domain containing ion transport regulator 6
GEM GTP binding protein overexpressed in skeletal muscle
HIST1H1C histone cluster 1, H1c
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
LRP2 low density lipoprotein receptor-related protein 2
NCAM1 neural cell adhesion molecule 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PELI1 pellino E3 ubiquitin protein ligase 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
RAB11FIP1 RAB11 family interacting protein 1 (class I)
SEPT2 septin 2
SQLE squalene epoxidase
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
USP10 ubiquitin specific peptidase 10

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACACA acetyl-CoA carboxylase alpha
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C2 aldo-keto reductase family 1, member C2
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATR ATR serine/threonine kinase
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
C2CD2 C2 calcium-dependent domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CADPS2 Ca++-dependent secretion activator 2
CANT1 calcium activated nucleotidase 1
CDK19 cyclin-dependent kinase 19
CEMIP cell migration inducing protein, hyaluronan binding
COA3 cytochrome c oxidase assembly factor 3
COCH cochlin
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EHBP1 EH domain binding protein 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
FAM208A family with sequence similarity 208, member A
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GOLGA8A golgin A8 family, member A
HOPX HOP homeobox
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JADE2 jade family PHD finger 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEPR leptin receptor
LIMCH1 LIM and calponin homology domains 1
LY6E lymphocyte antigen 6 complex, locus E
MAP2K5 mitogen-activated protein kinase kinase 5
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MRPS33 mitochondrial ribosomal protein S33
MTA1 metastasis associated 1
MTDH metadherin
MX2 MX dynamin-like GTPase 2
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
NISCH nischarin
NMT1 N-myristoyltransferase 1
NNMT nicotinamide N-methyltransferase
NSF N-ethylmaleimide-sensitive factor
NUP62 nucleoporin 62kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PDS5A PDS5 cohesin associated factor A
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLSCR3 phospholipid scramblase 3
PSD3 pleckstrin and Sec7 domain containing 3
PUS7 pseudouridylate synthase 7 (putative)
RABGAP1 RAB GTPase activating protein 1
RALBP1 ralA binding protein 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SETX senataxin
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX6 sorting nexin 6
SPATA20 spermatogenesis associated 20
SPDEF SAM pointed domain containing ETS transcription factor
SPG11 spastic paraplegia 11 (autosomal recessive)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TPM1 tropomyosin 1 (alpha)
TRIM14 tripartite motif containing 14
TRIM16 tripartite motif containing 16
UBE3C ubiquitin protein ligase E3C
VCAN versican
VPS13B vacuolar protein sorting 13 homolog B (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VWA8 von Willebrand factor A domain containing 8