BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

101 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
CLIC4 chloride intracellular channel 4
DDIT4 DNA-damage-inducible transcript 4
DUSP14 dual specificity phosphatase 14
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP4 fatty acid binding protein 4, adipocyte
FAM49A family with sequence similarity 49, member A
FERMT2 fermitin family member 2
HSPA13 heat shock protein 70kDa family, member 13
KLHL7 kelch-like family member 7
LAPTM4A lysosomal protein transmembrane 4 alpha
LTF lactotransferrin
MAP3K7CL MAP3K7 C-terminal like
MT1X metallothionein 1X
OSBPL8 oxysterol binding protein-like 8
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFN2 profilin 2
PLK1 polo-like kinase 1
PTN pleiotrophin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RYBP RING1 and YY1 binding protein
SCGB1D2 secretoglobin, family 1D, member 2
SEPT7 septin 7
SERTAD2 SERTA domain containing 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
USP1 ubiquitin specific peptidase 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AHCY adenosylhomocysteinase
AKR1C1 aldo-keto reductase family 1, member C1
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
ATR ATR serine/threonine kinase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1QBP complement component 1, q subcomponent binding protein
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative)
CHMP4A charged multivesicular body protein 4A
CLDN10 claudin 10
COA3 cytochrome c oxidase assembly factor 3
COMT catechol-O-methyltransferase
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EPRS glutamyl-prolyl-tRNA synthetase
FJX1 four jointed box 1 (Drosophila)
FXYD3 FXYD domain containing ion transport regulator 3
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KCTD12 potassium channel tetramerization domain containing 12
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
MANSC1 MANSC domain containing 1
MRPL12 mitochondrial ribosomal protein L12
MRPL24 mitochondrial ribosomal protein L24
MTA1 metastasis associated 1
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NHP2 NHP2 ribonucleoprotein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PGC progastricsin (pepsinogen C)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGIS prostaglandin I2 (prostacyclin) synthase
PUS7 pseudouridylate synthase 7 (putative)
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SRM spermidine synthase
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TGM2 transglutaminase 2
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TRIM16 tripartite motif containing 16
TRIP6 thyroid hormone receptor interactor 6
UBE3C ubiquitin protein ligase E3C
ZNF544 zinc finger protein 544
Funding