BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

253 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
ARL4C ADP-ribosylation factor-like 4C
BAMBI BMP and activin membrane-bound inhibitor
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BPI bactericidal/permeability-increasing protein
C7 complement component 7
CALD1 caldesmon 1
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CD46 CD46 molecule, complement regulatory protein
CD52 CD52 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLU clusterin
COL11A1 collagen, type XI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CTTN cortactin
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DEFA4 defensin, alpha 4, corticostatin
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
GABARAPL2 GABA(A) receptor-associated protein-like 2
GADD45B growth arrest and DNA-damage-inducible, beta
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSN gelsolin
HDAC9 histone deacetylase 9
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
JUND jun D proto-oncogene
LCN2 lipocalin 2
LGALS2 lectin, galactoside-binding, soluble, 2
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NCF1C neutrophil cytosolic factor 1C pseudogene
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PELI1 pellino E3 ubiquitin protein ligase 1
PLBD1 phospholipase B domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RPS5 ribosomal protein S5
S100A12 S100 calcium binding protein A12
SEPT2 septin 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SORT1 sortilin 1
SOX17 SRY (sex determining region Y)-box 17
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STK17B serine/threonine kinase 17b
TCL1A T-cell leukemia/lymphoma 1A
THBS1 thrombospondin 1
TMEM50B transmembrane protein 50B
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
USP1 ubiquitin specific peptidase 1
VAMP3 vesicle-associated membrane protein 3
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AGO2 argonaute RISC catalytic component 2
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
C2CD2 C2 calcium-dependent domain containing 2
C2CD5 C2 calcium-dependent domain containing 5
CAB39 calcium binding protein 39
CASP8AP2 caspase 8 associated protein 2
CBR3 carbonyl reductase 3
CCNF cyclin F
CDC14B cell division cycle 14B
CDC25B cell division cycle 25B
CDCP1 CUB domain containing protein 1
CDK12 cyclin-dependent kinase 12
CEP170 centrosomal protein 170kDa
CEP192 centrosomal protein 192kDa
CREB3L1 cAMP responsive element binding protein 3-like 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNMBP dynamin binding protein
DPP8 dipeptidyl-peptidase 8
DUSP4 dual specificity phosphatase 4
EDRF1 erythroid differentiation regulatory factor 1
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FMOD fibromodulin
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KIAA1033 KIAA1033
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KYNU kynureninase
LOC100272216 uncharacterized LOC100272216
MACF1 microtubule-actin crosslinking factor 1
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MDN1 MDN1, midasin homolog (yeast)
MED13 mediator complex subunit 13
MGA MGA, MAX dimerization protein
MGLL monoglyceride lipase
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTDH metadherin
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYO10 myosin X
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA6 nuclear receptor coactivator 6
NFX1 nuclear transcription factor, X-box binding 1
NMI N-myc (and STAT) interactor
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NPAT nuclear protein, ataxia-telangiectasia locus
NRP1 neuropilin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OLFML2B olfactomedin-like 2B
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCM1 pericentriolar material 1
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PRSS2 protease, serine, 2 (trypsin 2)
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSPC1 paraspeckle component 1
PTGES prostaglandin E synthase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RBM26 RNA binding motif protein 26
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
S100PBP S100P binding protein
SART3 squamous cell carcinoma antigen recognized by T cells 3
SETD5 SET domain containing 5
SETDB1 SET domain, bifurcated 1
SETX senataxin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD1 SMAD family member 1
SMC4 structural maintenance of chromosomes 4
SON SON DNA binding protein
SPATS2L spermatogenesis associated, serine-rich 2-like
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TBC1D31 TBC1 domain family, member 31
TBL1X transducin (beta)-like 1X-linked
TCERG1 transcription elongation regulator 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX10 testis expressed 10
TFF1 trefoil factor 1
TLK1 tousled-like kinase 1
TMEM194A transmembrane protein 194A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM44 tripartite motif containing 44
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZC3H13 zinc finger CCCH-type containing 13
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF451 zinc finger protein 451
ZW10 zw10 kinetochore protein