BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BTG3 BTG family, member 3
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
ELOVL4 ELOVL fatty acid elongase 4
EMP1 epithelial membrane protein 1
FRZB frizzled-related protein
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HIST2H2BE histone cluster 2, H2be
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
JAG1 jagged 1
LAMP3 lysosomal-associated membrane protein 3
LEPROT leptin receptor overlapping transcript
MMP9 matrix metallopeptidase 9
PCSK6 proprotein convertase subtilisin/kexin type 6
QPCT glutaminyl-peptide cyclotransferase
S100A12 S100 calcium binding protein A12
SPON1 spondin 1, extracellular matrix protein
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17

decreased expression

Symbol Name
ANKRD36B ankyrin repeat domain 36B
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
CCDC86 coiled-coil domain containing 86
CD58 CD58 molecule
CEP350 centrosomal protein 350kDa
CEP55 centrosomal protein 55kDa
DPP8 dipeptidyl-peptidase 8
DST dystonin
FHL2 four and a half LIM domains 2
GOLGA8A golgin A8 family, member A
HOOK2 hook microtubule-tethering protein 2
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS3 integrator complex subunit 3
JADE2 jade family PHD finger 2
KIF14 kinesin family member 14
KYNU kynureninase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MGLL monoglyceride lipase
MGP matrix Gla protein
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
PCM1 pericentriolar material 1
PHIP pleckstrin homology domain interacting protein
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCA protein kinase C, alpha
RPL31 ribosomal protein L31
SENP6 SUMO1/sentrin specific peptidase 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMC4 structural maintenance of chromosomes 4
SPDEF SAM pointed domain containing ETS transcription factor
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCERG1 transcription elongation regulator 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1A torsin family 1, member A (torsin A)
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE3C ubiquitin protein ligase E3C
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF638 zinc finger protein 638
ZNF652 zinc finger protein 652
Funding