BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

46 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AUTS2 autism susceptibility candidate 2
CALD1 caldesmon 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EPAS1 endothelial PAS domain protein 1
HBD hemoglobin, delta
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JAG1 jagged 1
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
PBX3 pre-B-cell leukemia homeobox 3
RAP1GAP RAP1 GTPase activating protein
STAB1 stabilin 1
TARP TCR gamma alternate reading frame protein

decreased expression

Symbol Name
ARFIP2 ADP-ribosylation factor interacting protein 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CCNA2 cyclin A2
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
ESR1 estrogen receptor 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD6 frizzled class receptor 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
ISG20 interferon stimulated exonuclease gene 20kDa
LDLR low density lipoprotein receptor
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NMI N-myc (and STAT) interactor
OAT ornithine aminotransferase
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAD51C RAD51 paralog C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM14A transmembrane protein 14A
TMEM251 transmembrane protein 251
TMEM5 transmembrane protein 5
TPD52L1 tumor protein D52-like 1
UBE2A ubiquitin-conjugating enzyme E2A