BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ALB albumin
APOB apolipoprotein B
ARG1 arginase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
CALD1 caldesmon 1
CAMP cathelicidin antimicrobial peptide
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CKB creatine kinase, brain
CLDN5 claudin 5
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
DSP desmoplakin
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSN gelsolin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HP haptoglobin
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITM2A integral membrane protein 2A
JAG1 jagged 1
JUP junction plakoglobin
KLF10 Kruppel-like factor 10
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MMP10 matrix metallopeptidase 10
MN1 meningioma (disrupted in balanced translocation) 1
MPO myeloperoxidase
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRG3 proteoglycan 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
RNF11 ring finger protein 11
S100A8 S100 calcium binding protein A8
SARAF store-operated calcium entry-associated regulatory factor
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
STK26 serine/threonine protein kinase 26
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARFIP2 ADP-ribosylation factor interacting protein 2
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CANT1 calcium activated nucleotidase 1
CASP8AP2 caspase 8 associated protein 2
CD44 CD44 molecule (Indian blood group)
CD58 CD58 molecule
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK12 cyclin-dependent kinase 12
COA3 cytochrome c oxidase assembly factor 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CX3CR1 chemokine (C-X3-C motif) receptor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM208A family with sequence similarity 208, member A
FAM216A family with sequence similarity 216, member A
FHL2 four and a half LIM domains 2
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GSAP gamma-secretase activating protein
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
HK1 hexokinase 1
IGFBP6 insulin-like growth factor binding protein 6
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGLL monoglyceride lipase
MPHOSPH8 M-phase phosphoprotein 8
MRPL12 mitochondrial ribosomal protein L12
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NFX1 nuclear transcription factor, X-box binding 1
NIPBL Nipped-B homolog (Drosophila)
NMI N-myc (and STAT) interactor
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUP62 nucleoporin 62kDa
ORC5 origin recognition complex, subunit 5
PDHX pyruvate dehydrogenase complex, component X
PDS5A PDS5 cohesin associated factor A
PFKP phosphofructokinase, platelet
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RANGRF RAN guanine nucleotide release factor
RPL31 ribosomal protein L31
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SETX senataxin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNUPN snurportin 1
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNRG synergin, gamma
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOX3 TOX high mobility group box family member 3
TRAPPC3 trafficking protein particle complex 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
UBE3C ubiquitin protein ligase E3C
UMPS uridine monophosphate synthetase
ZC3H4 zinc finger CCCH-type containing 4
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146
ZNF451 zinc finger protein 451