BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

414 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADCK3 aarF domain containing kinase 3
ADM adrenomedullin
AHSP alpha hemoglobin stabilizing protein
ALDOC aldolase C, fructose-bisphosphate
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLK BLK proto-oncogene, Src family tyrosine kinase
BRD2 bromodomain containing 2
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNJ cyclin J
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CLDN5 claudin 5
CLIC5 chloride intracellular channel 5
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
E2F2 E2F transcription factor 2
EFHD1 EF-hand domain family, member D1
ELANE elastase, neutrophil expressed
EMP1 epithelial membrane protein 1
F11R F11 receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GCG glucagon
GLS glutaminase
GMPR guanosine monophosphate reductase
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBD hemoglobin, delta
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP5 insulin-like growth factor binding protein 5
IGSF1 immunoglobulin superfamily, member 1
INSM1 insulinoma-associated 1
IQGAP1 IQ motif containing GTPase activating protein 1
JAG1 jagged 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF13 Kruppel-like factor 13
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
LTB lymphotoxin beta (TNF superfamily, member 3)
LUZP1 leucine zipper protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKSL1 MARCKS-like 1
MCOLN1 mucolipin 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MSX1 msh homeobox 1
NDRG1 N-myc downstream regulated 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
PCDH9 protocadherin 9
PDE2A phosphodiesterase 2A, cGMP-stimulated
PELI1 pellino E3 ubiquitin protein ligase 1
PHACTR1 phosphatase and actin regulator 1
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRDM2 PR domain containing 2, with ZNF domain
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRNP prion protein
PRTN3 proteinase 3
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB14 RAB14, member RAS oncogene family
RAP2A RAP2A, member of RAS oncogene family
RGCC regulator of cell cycle
RHAG Rh-associated glycoprotein
RNF11 ring finger protein 11
RTN1 reticulon 1
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S1PR1 sphingosine-1-phosphate receptor 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SI sucrase-isomaltase (alpha-glucosidase)
SLAMF7 SLAM family member 7
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMIM7 small integral membrane protein 7
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
TACC1 transforming, acidic coiled-coil containing protein 1
TCF3 transcription factor 3
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP3 TIMP metallopeptidase inhibitor 3
TP53BP2 tumor protein p53 binding protein 2
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR47 WD repeat domain 47
WISP2 WNT1 inducible signaling pathway protein 2
WT1 Wilms tumor 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABLIM1 actin binding LIM protein 1
ACO1 aconitase 1, soluble
ACSF2 acyl-CoA synthetase family member 2
ADGRE5 adhesion G protein-coupled receptor E5
AK2 adenylate kinase 2
AKAP10 A kinase (PRKA) anchor protein 10
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ALG6 ALG6, alpha-1,3-glucosyltransferase
ALG8 ALG8, alpha-1,3-glucosyltransferase
ANXA10 annexin A10
ARFIP2 ADP-ribosylation factor interacting protein 2
ASCC3 activating signal cointegrator 1 complex subunit 3
ASL argininosuccinate lyase
ATF6 activating transcription factor 6
ATG7 autophagy related 7
ATR ATR serine/threonine kinase
B9D1 B9 protein domain 1
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1RL complement component 1, r subcomponent-like
C2CD5 C2 calcium-dependent domain containing 5
C4ORF27 chromosome 4 open reading frame 27
C6ORF120 chromosome 6 open reading frame 120
CBS cystathionine-beta-synthase
CCDC90B coiled-coil domain containing 90B
CDC25B cell division cycle 25B
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLGN calmegin
CNPY2 canopy FGF signaling regulator 2
COA3 cytochrome c oxidase assembly factor 3
COG2 component of oligomeric golgi complex 2
COMT catechol-O-methyltransferase
COPS6 COP9 signalosome subunit 6
COPS7A COP9 signalosome subunit 7A
CPD carboxypeptidase D
CTPS1 CTP synthase 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDT D-dopachrome tautomerase
DEFB1 defensin, beta 1
DENND2D DENN/MADD domain containing 2D
DESI1 desumoylating isopeptidase 1
DRAM1 DNA-damage regulated autophagy modulator 1
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENOSF1 enolase superfamily member 1
ERBB3 erb-b2 receptor tyrosine kinase 3
ERGIC2 ERGIC and golgi 2
ETNK1 ethanolamine kinase 1
ETV5 ets variant 5
EXOSC4 exosome component 4
FADS1 fatty acid desaturase 1
FAM216A family with sequence similarity 216, member A
FAM57A family with sequence similarity 57, member A
FBP1 fructose-1,6-bisphosphatase 1
FBXO9 F-box protein 9
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
FOLR1 folate receptor 1 (adult)
GALE UDP-galactose-4-epimerase
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCAT glycine C-acetyltransferase
GCDH glutaryl-CoA dehydrogenase
GEMIN6 gem (nuclear organelle) associated protein 6
GMPPB GDP-mannose pyrophosphorylase B
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSTK1 glutathione S-transferase kappa 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GTPBP8 GTP-binding protein 8 (putative)
HAUS4 HAUS augmin-like complex, subunit 4
HDDC2 HD domain containing 2
HEATR1 HEAT repeat containing 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICA1 islet cell autoantigen 1, 69kDa
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KIAA0391 KIAA0391
KIAA0485 uncharacterized LOC57235
KLK11 kallikrein-related peptidase 11
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP10 low density lipoprotein receptor-related protein 10
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MANSC1 MANSC domain containing 1
MAPK13 mitogen-activated protein kinase 13
MATN2 matrilin 2
MECOM MDS1 and EVI1 complex locus
MEIS1 Meis homeobox 1
MEIS3P1 Meis homeobox 3 pseudogene 1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MPRIP myosin phosphatase Rho interacting protein
MPV17 MpV17 mitochondrial inner membrane protein
MRPL12 mitochondrial ribosomal protein L12
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MRPS33 mitochondrial ribosomal protein S33
MRPS35 mitochondrial ribosomal protein S35
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
MYCBP MYC binding protein
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NUP210 nucleoporin 210kDa
NUP88 nucleoporin 88kDa
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXA1L oxidase (cytochrome c) assembly 1-like
OXLD1 oxidoreductase-like domain containing 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAAF1 proteasomal ATPase-associated factor 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM4 PDZ and LIM domain 4
PFAS phosphoribosylformylglycinamidine synthase
PFKP phosphofructokinase, platelet
PILRB paired immunoglobin-like type 2 receptor beta
PITX1 paired-like homeodomain 1
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLSCR1 phospholipid scramblase 1
PLSCR3 phospholipid scramblase 3
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNKP polynucleotide kinase 3'-phosphatase
PNMA2 paraneoplastic Ma antigen 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGES prostaglandin E synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
RAD51C RAD51 paralog C
RBPMS RNA binding protein with multiple splicing
RPA3 replication protein A3, 14kDa
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
RUVBL2 RuvB-like AAA ATPase 2
RWDD2B RWD domain containing 2B
S100P S100 calcium binding protein P
SCG5 secretogranin V
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A10 solute carrier family 38, member 10
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPAG4 sperm associated antigen 4
SPATA20 spermatogenesis associated 20
SPATS2L spermatogenesis associated, serine-rich 2-like
SPG11 spastic paraplegia 11 (autosomal recessive)
SRPRB signal recognition particle receptor, B subunit
SRRD SRR1 domain containing
STAMBP STAM binding protein
STRA13 stimulated by retinoic acid 13
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SVIL supervillin
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM126B transmembrane protein 126B
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM223 transmembrane protein 223
TMEM5 transmembrane protein 5
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOM1L1 target of myb1 (chicken)-like 1
TOX thymocyte selection-associated high mobility group box
TP53BP1 tumor protein p53 binding protein 1
TPCN1 two pore segment channel 1
TPGS2 tubulin polyglutamylase complex subunit 2
TRAPPC12 trafficking protein particle complex 12
TRIM16 tripartite motif containing 16
TRIOBP TRIO and F-actin binding protein
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TYMP thymidine phosphorylase
TYMS thymidylate synthetase
UBE3C ubiquitin protein ligase E3C
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
UMPS uridine monophosphate synthetase
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VWA8 von Willebrand factor A domain containing 8
WDR77 WD repeat domain 77
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF692 zinc finger protein 692
ZYX zyxin