BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

227 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD11 ankyrin repeat domain 11
ANOS1 anosmin 1
APLP1 amyloid beta (A4) precursor-like protein 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPN asporin
BMP2 bone morphogenetic protein 2
C3 complement component 3
CA1 carbonic anhydrase I
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND2 cyclin D2
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CD52 CD52 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
CFH complement factor H
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHCR24 24-dehydrocholesterol reductase
DPT dermatopontin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
ENDOD1 endonuclease domain containing 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FGFR3 fibroblast growth factor receptor 3
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FXYD3 FXYD domain containing ion transport regulator 3
GAL galanin/GMAP prepropeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GSN gelsolin
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
INHBA inhibin, beta A
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KRT8 keratin 8, type II
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LYZ lysozyme
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OLFML3 olfactomedin-like 3
PCDH17 protocadherin 17
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
SARAF store-operated calcium entry-associated regulatory factor
SCG2 secretogranin II
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SERINC5 serine incorporator 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP1 S-phase kinase-associated protein 1
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SST somatostatin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STS steroid sulfatase (microsomal), isozyme S
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM47 transmembrane protein 47
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VAMP3 vesicle-associated membrane protein 3
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADM adrenomedullin
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
BLM Bloom syndrome, RecQ helicase-like
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD200 CD200 molecule
CDC25B cell division cycle 25B
CDH18 cadherin 18, type 2
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHMP6 charged multivesicular body protein 6
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLTA clathrin, light chain A
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP5 dual specificity phosphatase 5
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF5 eukaryotic translation initiation factor 5
FHL2 four and a half LIM domains 2
GSPT2 G1 to S phase transition 2
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GTSE1 G-2 and S-phase expressed 1
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
IGFBP4 insulin-like growth factor binding protein 4
IGHD immunoglobulin heavy constant delta
INPP1 inositol polyphosphate-1-phosphatase
IRF2 interferon regulatory factor 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIF18B kinesin family member 18B
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
N4BP2L2 NEDD4 binding protein 2-like 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAV2 neuron navigator 2
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NRG1 neuregulin 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDHX pyruvate dehydrogenase complex, component X
PFKP phosphofructokinase, platelet
PLIN2 perilipin 2
PRPF4 pre-mRNA processing factor 4
PSRC1 proline/serine-rich coiled-coil 1
PTX3 pentraxin 3, long
PXDC1 PX domain containing 1
RAD9A RAD9 homolog A (S. pombe)
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RBM47 RNA binding motif protein 47
S100A7 S100 calcium binding protein A7
SALL1 spalt-like transcription factor 1
SCAND1 SCAN domain containing 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIP6 thyroid hormone receptor interactor 6
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF146 zinc finger protein 146
Funding