BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

342 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADGRL2 adhesion G protein-coupled receptor L2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ANKRD11 ankyrin repeat domain 11
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD163 CD163 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDO1 cysteine dioxygenase type 1
CHGB chromogranin B
CLDN5 claudin 5
COL6A1 collagen, type VI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DCN decorin
DPT dermatopontin
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F11R F11 receptor
FAM198B family with sequence similarity 198, member B
FAM49A family with sequence similarity 49, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO1 forkhead box O1
FOXO4 forkhead box O4
FRZB frizzled-related protein
FST follistatin
GLUL glutamate-ammonia ligase
GPC1 glypican 1
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
H2AFV H2A histone family, member V
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
IRF8 interferon regulatory factor 8
JAG1 jagged 1
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LAPTM5 lysosomal protein transmembrane 5
LPAR6 lysophosphatidic acid receptor 6
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MXRA5 matrix-remodelling associated 5
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NUAK1 NUAK family, SNF1-like kinase, 1
PCDH9 protocadherin 9
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PLEK pleckstrin
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PTHLH parathyroid hormone-like hormone
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMIM7 small integral membrane protein 7
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SPARCL1 SPARC-like 1 (hevin)
TGOLN2 trans-golgi network protein 2
THBD thrombomodulin
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF551 zinc finger protein 551
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSF2 acyl-CoA synthetase family member 2
ADSL adenylosuccinate lyase
AHI1 Abelson helper integration site 1
AK1 adenylate kinase 1
AK2 adenylate kinase 2
AKAP10 A kinase (PRKA) anchor protein 10
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALG6 ALG6, alpha-1,3-glucosyltransferase
AMDHD2 amidohydrolase domain containing 2
ANXA3 annexin A3
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
AURKB aurora kinase B
B9D1 B9 protein domain 1
BAG1 BCL2-associated athanogene
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIN1 bridging integrator 1
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
C16ORF45 chromosome 16 open reading frame 45
C17ORF62 chromosome 17 open reading frame 62
C1RL complement component 1, r subcomponent-like
C4ORF27 chromosome 4 open reading frame 27
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CBX6 chromobox homolog 6
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CEP55 centrosomal protein 55kDa
CHMP6 charged multivesicular body protein 6
CIT citron rho-interacting serine/threonine kinase
CLCN3 chloride channel, voltage-sensitive 3
CNN1 calponin 1, basic, smooth muscle
COA3 cytochrome c oxidase assembly factor 3
COMMD4 COMM domain containing 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DENND5A DENN/MADD domain containing 5A
DERA deoxyribose-phosphate aldolase (putative)
DESI1 desumoylating isopeptidase 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLC1 DLC1 Rho GTPase activating protein
DNM1 dynamin 1
EBP emopamil binding protein (sterol isomerase)
EFCAB11 EF-hand calcium binding domain 11
EIF4B eukaryotic translation initiation factor 4B
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EPN2 epsin 2
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM216A family with sequence similarity 216, member A
FOLR1 folate receptor 1 (adult)
FZD2 frizzled class receptor 2
GALE UDP-galactose-4-epimerase
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GMPPB GDP-mannose pyrophosphorylase B
GSS glutathione synthetase
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAUS4 HAUS augmin-like complex, subunit 4
HDDC2 HD domain containing 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IFRD2 interferon-related developmental regulator 2
IL6ST interleukin 6 signal transducer
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
KIAA0391 KIAA0391
KLC1 kinesin light chain 1
KRT7 keratin 7, type II
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAB21L2 mab-21-like 2 (C. elegans)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MPRIP myosin phosphatase Rho interacting protein
MRPL12 mitochondrial ribosomal protein L12
MRPL17 mitochondrial ribosomal protein L17
MRPS16 mitochondrial ribosomal protein S16
MSLN mesothelin
MSRB1 methionine sulfoxide reductase B1
MTCL1 microtubule crosslinking factor 1
MYBPC1 myosin binding protein C, slow type
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYLK myosin light chain kinase
MYOF myoferlin
NAV2 neuron navigator 2
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
OXTR oxytocin receptor
PAAF1 proteasomal ATPase-associated factor 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PALLD palladin, cytoskeletal associated protein
PCYOX1L prenylcysteine oxidase 1 like
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM4 PDZ and LIM domain 4
PDLIM5 PDZ and LIM domain 5
PFKP phosphofructokinase, platelet
PLAC8 placenta-specific 8
PNKP polynucleotide kinase 3'-phosphatase
PNMA2 paraneoplastic Ma antigen 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PTGES prostaglandin E synthase
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RMI1 RecQ mediated genome instability 1
RPA3 replication protein A3, 14kDa
RPL39L ribosomal protein L39-like
RPS27L ribosomal protein S27-like
RUNX1 runt-related transcription factor 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SETD5 SET domain containing 5
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNF8 SNF8, ESCRT-II complex subunit
SNX11 sorting nexin 11
SVIL supervillin
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TDP1 tyrosyl-DNA phosphodiesterase 1
TESC tescalcin
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TPGS2 tubulin polyglutamylase complex subunit 2
TPI1 triosephosphate isomerase 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRAK2 trafficking protein, kinesin binding 2
TRIM16 tripartite motif containing 16
TRIOBP TRIO and F-actin binding protein
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR6 WD repeat domain 6
WDR61 WD repeat domain 61
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZNF185 zinc finger protein 185 (LIM domain)