BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

357 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AGA aspartylglucosaminidase
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANO1 anoctamin 1, calcium activated chloride channel
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C3 complement component 3
CA2 carbonic anhydrase II
CANX calnexin
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD52 CD52 molecule
CD93 CD93 molecule
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CRP C-reactive protein, pentraxin-related
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
EXPH5 exophilin 5
FABP4 fatty acid binding protein 4, adipocyte
FAM198B family with sequence similarity 198, member B
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FPR1 formyl peptide receptor 1
FZD1 frizzled class receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GGCX gamma-glutamyl carboxylase
GMFG glia maturation factor, gamma
GNMT glycine N-methyltransferase
GSN gelsolin
HIST1H2BD histone cluster 1, H2bd
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA13 heat shock protein 70kDa family, member 13
IER3 immediate early response 3
IFT57 intraflagellar transport 57
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGLL1 immunoglobulin lambda-like polypeptide 1
IL7R interleukin 7 receptor
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
KRT5 keratin 5, type II
L1CAM L1 cell adhesion molecule
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
LY96 lymphocyte antigen 96
MAOB monoamine oxidase B
MAPK1 mitogen-activated protein kinase 1
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NEFH neurofilament, heavy polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCDH7 protocadherin 7
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PNPLA4 patatin-like phospholipase domain containing 4
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTTG1IP pituitary tumor-transforming 1 interacting protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNF130 ring finger protein 130
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SELENBP1 selenium binding protein 1
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
STK17B serine/threonine kinase 17b
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TDO2 tryptophan 2,3-dioxygenase
TFR2 transferrin receptor 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMED5 transmembrane emp24 protein transport domain containing 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TTC3 tetratricopeptide repeat domain 3
VAMP3 vesicle-associated membrane protein 3
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2
WLS wntless Wnt ligand secretion mediator
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACBD3 acyl-CoA binding domain containing 3
AFF1 AF4/FMR2 family, member 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
ARHGAP12 Rho GTPase activating protein 12
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARID4B AT rich interactive domain 4B (RBP1-like)
ASXL2 additional sex combs like transcriptional regulator 2
ATF1 activating transcription factor 1
ATF7IP activating transcription factor 7 interacting protein
AURKA aurora kinase A
AURKB aurora kinase B
AXIN1 axin 1
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BLM Bloom syndrome, RecQ helicase-like
BMPR1A bone morphogenetic protein receptor, type IA
BRCA1 breast cancer 1, early onset
BRPF1 bromodomain and PHD finger containing, 1
C2CD5 C2 calcium-dependent domain containing 5
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNF cyclin F
CDC14B cell division cycle 14B
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK12 cyclin-dependent kinase 12
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP350 centrosomal protein 350kDa
CHD9 chromodomain helicase DNA binding protein 9
CHMP6 charged multivesicular body protein 6
CHSY1 chondroitin sulfate synthase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
DCLRE1C DNA cross-link repair 1C
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EDRF1 erythroid differentiation regulatory factor 1
EFHD2 EF-hand domain family, member D2
ETV5 ets variant 5
EXOSC4 exosome component 4
FAM134C family with sequence similarity 134, member C
FAM193A family with sequence similarity 193, member A
FAM216A family with sequence similarity 216, member A
FAM222B family with sequence similarity 222, member B
FAM57A family with sequence similarity 57, member A
FGF13 fibroblast growth factor 13
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLDC glycine dehydrogenase (decarboxylating)
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GRB10 growth factor receptor-bound protein 10
HK1 hexokinase 1
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
IGFBP4 insulin-like growth factor binding protein 4
IGHA1 immunoglobulin heavy constant alpha 1
INSL4 insulin-like 4 (placenta)
INTS6 integrator complex subunit 6
IRF2 interferon regulatory factor 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KANK2 KN motif and ankyrin repeat domains 2
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KIAA0355 KIAA0355
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRBOX4 KRAB box domain containing 4
LARP4B La ribonucleoprotein domain family, member 4B
LDHB lactate dehydrogenase B
LOC100272216 uncharacterized LOC100272216
MED1 mediator complex subunit 1
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MGA MGA, MAX dimerization protein
MGLL monoglyceride lipase
MID1 midline 1
MPRIP myosin phosphatase Rho interacting protein
MYO10 myosin X
MYO1E myosin IE
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NDE1 nudE neurodevelopment protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NMT1 N-myristoyltransferase 1
NOTCH2NL notch 2 N-terminal like
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PFKP phosphofructokinase, platelet
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G16 phospholipase A2, group XVI
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNISR PNN-interacting serine/arginine-rich protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PRKCA protein kinase C, alpha
PSPC1 paraspeckle component 1
PTGES prostaglandin E synthase
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PURA purine-rich element binding protein A
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAD9A RAD9 homolog A (S. pombe)
RGS2 regulator of G-protein signaling 2
RNF111 ring finger protein 111
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SEPHS1 selenophosphate synthetase 1
SETD5 SET domain containing 5
SETX senataxin
SFRP1 secreted frizzled-related protein 1
SIRT1 sirtuin 1
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNX11 sorting nexin 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNRG synergin, gamma
TBL1X transducin (beta)-like 1X-linked
TBX3 T-box 3
TCERG1 transcription elongation regulator 1
TCF4 transcription factor 4
TESC tescalcin
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TOX3 TOX high mobility group box family member 3
TRAK2 trafficking protein, kinesin binding 2
TSC22D2 TSC22 domain family, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPYL5 TSPY-like 5
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP6NL USP6 N-terminal like
VAV3 vav 3 guanine nucleotide exchange factor
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF146 zinc finger protein 146
ZNF189 zinc finger protein 189
ZNF266 zinc finger protein 266
ZNF282 zinc finger protein 282
ZNF451 zinc finger protein 451