BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

300 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BMP2 bone morphogenetic protein 2
C1QA complement component 1, q subcomponent, A chain
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CAPG capping protein (actin filament), gelsolin-like
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNA1 cyclin A1
CD14 CD14 molecule
CD163 CD163 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRP C-reactive protein, pentraxin-related
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
EXPH5 exophilin 5
FAM198B family with sequence similarity 198, member B
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GNMT glycine N-methyltransferase
GPNMB glycoprotein (transmembrane) nmb
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HTRA1 HtrA serine peptidase 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
IL7R interleukin 7 receptor
INSM1 insulinoma-associated 1
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LGALS3 lectin, galactoside-binding, soluble, 3
LRRC17 leucine rich repeat containing 17
LYZ lysozyme
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYL9 myosin, light chain 9, regulatory
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDRG1 N-myc downstream regulated 1
NRIP3 nuclear receptor interacting protein 3
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PLVAP plasmalemma vesicle associated protein
PTHLH parathyroid hormone-like hormone
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCG2 secretogranin II
SDC2 syndecan 2
SDC4 syndecan 4
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SHB Src homology 2 domain containing adaptor protein B
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SOCS2 suppressor of cytokine signaling 2
SPARCL1 SPARC-like 1 (hevin)
TAGLN transgelin
TDO2 tryptophan 2,3-dioxygenase
TF transferrin
TFR2 transferrin receptor 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM9SF3 transmembrane 9 superfamily member 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
TRIM36 tripartite motif containing 36
TUBB2A tubulin, beta 2A class IIa
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WT1 Wilms tumor 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALG6 ALG6, alpha-1,3-glucosyltransferase
ARFIP2 ADP-ribosylation factor interacting protein 2
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPH aspartate beta-hydroxylase
ASXL2 additional sex combs like transcriptional regulator 2
ATF1 activating transcription factor 1
ATR ATR serine/threonine kinase
BAG2 BCL2-associated athanogene 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
C4ORF27 chromosome 4 open reading frame 27
C8ORF4 chromosome 8 open reading frame 4
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CBX6 chromobox homolog 6
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COG2 component of oligomeric golgi complex 2
COG4 component of oligomeric golgi complex 4
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DERA deoxyribose-phosphate aldolase (putative)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DZIP3 DAZ interacting zinc finger protein 3
EAPP E2F-associated phosphoprotein
EFCAB11 EF-hand calcium binding domain 11
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENOSF1 enolase superfamily member 1
FA2H fatty acid 2-hydroxylase
FAM208A family with sequence similarity 208, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FXYD2 FXYD domain containing ion transport regulator 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLRX glutaredoxin (thioltransferase)
GOLGA8A golgin A8 family, member A
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GSTA4 glutathione S-transferase alpha 4
HAUS4 HAUS augmin-like complex, subunit 4
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP4 insulin-like growth factor binding protein 4
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSL4 insulin-like 4 (placenta)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0391 KIAA0391
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KYNU kynureninase
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LXN latexin
MAP2K6 mitogen-activated protein kinase kinase 6
MEIS3P1 Meis homeobox 3 pseudogene 1
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MREG melanoregulin
MTA1 metastasis associated 1
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NIT2 nitrilase family, member 2
NMI N-myc (and STAT) interactor
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
NUP210 nucleoporin 210kDa
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PLAC8 placenta-specific 8
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNISR PNN-interacting serine/arginine-rich protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PRKCA protein kinase C, alpha
PROM1 prominin 1
PTER phosphotriesterase related
PTGES prostaglandin E synthase
RAD51C RAD51 paralog C
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RFC4 replication factor C (activator 1) 4, 37kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RMI1 RecQ mediated genome instability 1
RPL39L ribosomal protein L39-like
SEC23IP SEC23 interacting protein
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC16A4 solute carrier family 16, member 4
SLC35B1 solute carrier family 35, member B1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX11 sorting nexin 11
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRP54 signal recognition particle 54kDa
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TIMP4 TIMP metallopeptidase inhibitor 4
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TOM1L1 target of myb1 (chicken)-like 1
TOX3 TOX high mobility group box family member 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TUBB6 tubulin, beta 6 class V
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WDR6 WD repeat domain 6
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6