BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

332 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ADAMDEC1 ADAM-like, decysin 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
BEX4 brain expressed, X-linked 4
BIRC7 baculoviral IAP repeat containing 7
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCK cholecystokinin
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSTA cystatin A (stefin A)
CTTN cortactin
DEFA4 defensin, alpha 4, corticostatin
DIDO1 death inducer-obliterator 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
F11R F11 receptor
FAM171A1 family with sequence similarity 171, member A1
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GCG glucagon
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA5 homeobox A5
HP haptoglobin
HSBP1 heat shock factor binding protein 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGLL1 immunoglobulin lambda-like polypeptide 1
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LGALS2 lectin, galactoside-binding, soluble, 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK1 mitogen-activated protein kinase 1
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PELI1 pellino E3 ubiquitin protein ligase 1
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF11 ring finger protein 11
RNF139 ring finger protein 139
RRAD Ras-related associated with diabetes
S100A8 S100 calcium binding protein A8
SELENBP1 selenium binding protein 1
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGR SH3 domain binding glutamate-rich protein
SIK1 salt-inducible kinase 1
SKP1 S-phase kinase-associated protein 1
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
SON SON DNA binding protein
SORT1 sortilin 1
SOX4 SRY (sex determining region Y)-box 4
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STK17B serine/threonine kinase 17b
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TMEM110 transmembrane protein 110
TMEM45A transmembrane protein 45A
TMEM50B transmembrane protein 50B
TNNT1 troponin T type 1 (skeletal, slow)
TOX thymocyte selection-associated high mobility group box
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UGCG UDP-glucose ceramide glucosyltransferase
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VAMP3 vesicle-associated membrane protein 3
VNN1 vanin 1
WDR47 WD repeat domain 47
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACOX2 acyl-CoA oxidase 2, branched chain
AIM1 absent in melanoma 1
AMACR alpha-methylacyl-CoA racemase
ANKRD17 ankyrin repeat domain 17
ANKRD36B ankyrin repeat domain 36B
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
ATF7IP activating transcription factor 7 interacting protein
ATP13A3 ATPase type 13A3
ATR ATR serine/threonine kinase
AVL9 AVL9 homolog (S. cerevisiase)
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CASP8AP2 caspase 8 associated protein 2
CBX5 chromobox homolog 5
CCND2 cyclin D2
CCNF cyclin F
CD58 CD58 molecule
CDC25B cell division cycle 25B
CDK12 cyclin-dependent kinase 12
CDK14 cyclin-dependent kinase 14
CEMIP cell migration inducing protein, hyaluronan binding
CEP170 centrosomal protein 170kDa
CEP192 centrosomal protein 192kDa
CEP55 centrosomal protein 55kDa
CHD9 chromodomain helicase DNA binding protein 9
CNOT4 CCR4-NOT transcription complex, subunit 4
CPD carboxypeptidase D
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
DCAF10 DDB1 and CUL4 associated factor 10
DENND4C DENN/MADD domain containing 4C
DIXDC1 DIX domain containing 1
DMXL2 Dmx-like 2
DPP8 dipeptidyl-peptidase 8
DST dystonin
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EDRF1 erythroid differentiation regulatory factor 1
EFTUD1 elongation factor Tu GTP binding domain containing 1
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELOVL6 ELOVL fatty acid elongase 6
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
FAM208A family with sequence similarity 208, member A
FAM216A family with sequence similarity 216, member A
FBXW2 F-box and WD repeat domain containing 2
FMOD fibromodulin
FNDC3B fibronectin type III domain containing 3B
FOXD1 forkhead box D1
FXYD5 FXYD domain containing ion transport regulator 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GOLGA8A golgin A8 family, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
INTS6 integrator complex subunit 6
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KIF14 kinesin family member 14
KIF3B kinesin family member 3B
KPNB1 karyopherin (importin) beta 1
KRIT1 KRIT1, ankyrin repeat containing
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LARP4 La ribonucleoprotein domain family, member 4
LOC100272216 uncharacterized LOC100272216
LRRC16A leucine rich repeat containing 16A
MACF1 microtubule-actin crosslinking factor 1
MAP2K5 mitogen-activated protein kinase kinase 5
MBNL2 muscleblind-like splicing regulator 2
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGA MGA, MAX dimerization protein
MGLL monoglyceride lipase
MPHOSPH8 M-phase phosphoprotein 8
MTCL1 microtubule crosslinking factor 1
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NCOA6 nuclear receptor coactivator 6
NF1 neurofibromin 1
NFIB nuclear factor I/B
NFX1 nuclear transcription factor, X-box binding 1
NIPBL Nipped-B homolog (Drosophila)
NMT1 N-myristoyltransferase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOTCH2NL notch 2 N-terminal like
NPAT nuclear protein, ataxia-telangiectasia locus
NRCAM neuronal cell adhesion molecule
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PCM1 pericentriolar material 1
PDLIM5 PDZ and LIM domain 5
PDS5A PDS5 cohesin associated factor A
PFKP phosphofructokinase, platelet
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTGES prostaglandin E synthase
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic)
RBM26 RNA binding motif protein 26
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RNF111 ring finger protein 111
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
SCAF11 SR-related CTD-associated factor 11
SENP6 SUMO1/sentrin specific peptidase 6
SETD5 SET domain containing 5
SETDB1 SET domain, bifurcated 1
SETX senataxin
SH3BP4 SH3-domain binding protein 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPG11 spastic paraplegia 11 (autosomal recessive)
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNRG synergin, gamma
TBC1D31 TBC1 domain family, member 31
TBL2 transducin (beta)-like 2
TCERG1 transcription elongation regulator 1
TDP1 tyrosyl-DNA phosphodiesterase 1
TERF2 telomeric repeat binding factor 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLK1 tousled-like kinase 1
TMEM194A transmembrane protein 194A
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TMEM63A transmembrane protein 63A
TOM1L1 target of myb1 (chicken)-like 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TRAPPC12 trafficking protein particle complex 12
TRIM14 tripartite motif containing 14
TRIM44 tripartite motif containing 44
TRIP6 thyroid hormone receptor interactor 6
TRRAP transformation/transcription domain-associated protein
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TUBGCP3 tubulin, gamma complex associated protein 3
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
VCAN versican
ZC3H13 zinc finger CCCH-type containing 13
ZC3H4 zinc finger CCCH-type containing 4
ZHX2 zinc fingers and homeoboxes 2
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF131 zinc finger protein 131
ZNF146 zinc finger protein 146
ZNF451 zinc finger protein 451
ZNF573 zinc finger protein 573
ZNF638 zinc finger protein 638