BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

391 genes differentially expressed following the BRD-K84203638_4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD4 bromodomain containing 4
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA1 cyclin A1
CCR2 chemokine (C-C motif) receptor 2
CD163 CD163 molecule
CD86 CD86 molecule
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CELF2 CUGBP, Elav-like family member 2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP2B charged multivesicular body protein 2B
CHMP5 charged multivesicular body protein 5
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
CYTIP cytohesin 1 interacting protein
DESI2 desumoylating isopeptidase 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSC1 desmocollin 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPAS1 endothelial PAS domain protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP1 fatty acid binding protein 1, liver
FAM49A family with sequence similarity 49, member A
FAM69A family with sequence similarity 69, member A
FHL2 four and a half LIM domains 2
FILIP1L filamin A interacting protein 1-like
FLNC filamin C, gamma
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GIMAP6 GTPase, IMAP family member 6
GJA1 gap junction protein, alpha 1, 43kDa
GLS glutaminase
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEPH hephaestin
HIC2 hypermethylated in cancer 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFRD1 interferon-related developmental regulator 1
IL1RL1 interleukin 1 receptor-like 1
ISOC1 isochorismatase domain containing 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL7 kelch-like family member 7
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K1 mitogen-activated protein kinase kinase 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MEST mesoderm specific transcript
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYO1D myosin ID
NCF4 neutrophil cytosolic factor 4, 40kDa
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PADI2 peptidyl arginine deiminase, type II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PDZD2 PDZ domain containing 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2
PLXNA2 plexin A2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF11 ring finger protein 11
RTN2 reticulon 2
RYBP RING1 and YY1 binding protein
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SFN stratifin
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOCS2 suppressor of cytokine signaling 2
SOX17 SRY (sex determining region Y)-box 17
SQLE squalene epoxidase
SRGN serglycin
STK17B serine/threonine kinase 17b
STX3 syntaxin 3
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TES testin LIM domain protein
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
WIF1 WNT inhibitory factor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACADVL acyl-CoA dehydrogenase, very long chain
ACP6 acid phosphatase 6, lysophosphatidic
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALG6 ALG6, alpha-1,3-glucosyltransferase
ASB9 ankyrin repeat and SOCS box containing 9
ASCC3 activating signal cointegrator 1 complex subunit 3
ATF6 activating transcription factor 6
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATR ATR serine/threonine kinase
AURKB aurora kinase B
BACE2 beta-site APP-cleaving enzyme 2
BBS1 Bardet-Biedl syndrome 1
BCHE butyrylcholinesterase
BRCA1 breast cancer 1, early onset
BTN3A2 butyrophilin, subfamily 3, member A2
C1RL complement component 1, r subcomponent-like
C3 complement component 3
C6ORF120 chromosome 6 open reading frame 120
CBR3 carbonyl reductase 3
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CFB complement factor B
COA3 cytochrome c oxidase assembly factor 3
COG4 component of oligomeric golgi complex 4
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COPS6 COP9 signalosome subunit 6
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DALRD3 DALR anticodon binding domain containing 3
DCPS decapping enzyme, scavenger
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNM1 dynamin 1
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
EPHA3 EPH receptor A3
ESYT1 extended synaptotagmin-like protein 1
ETFB electron-transfer-flavoprotein, beta polypeptide
F12 coagulation factor XII (Hageman factor)
FABP7 fatty acid binding protein 7, brain
FBN2 fibrillin 2
FKBP10 FK506 binding protein 10, 65 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
G6PC3 glucose 6 phosphatase, catalytic, 3
GAA glucosidase, alpha; acid
GALE UDP-galactose-4-epimerase
GANAB glucosidase, alpha; neutral AB
GSAP gamma-secretase activating protein
GSTA4 glutathione S-transferase alpha 4
HACD1 3-hydroxyacyl-CoA dehydratase 1
HLA-C major histocompatibility complex, class I, C
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGA2 high mobility group AT-hook 2
IL6ST interleukin 6 signal transducer
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JADE2 jade family PHD finger 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHL9 kelch-like family member 9
KRT13 keratin 13, type I
KRT18 keratin 18, type I
KYNU kynureninase
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LAMB2 laminin, beta 2 (laminin S)
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP10 low density lipoprotein receptor-related protein 10
LTBP3 latent transforming growth factor beta binding protein 3
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2B1 mannosidase, alpha, class 2B, member 1
MANSC1 MANSC domain containing 1
MAP1B microtubule-associated protein 1B
MAP2K6 mitogen-activated protein kinase kinase 6
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MCM3 minichromosome maintenance complex component 3
MET MET proto-oncogene, receptor tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MIA melanoma inhibitory activity
MRPL12 mitochondrial ribosomal protein L12
MSRB2 methionine sulfoxide reductase B2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MVP major vault protein
MYH10 myosin, heavy chain 10, non-muscle
N4BP2L2 NEDD4 binding protein 2-like 2
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNT nicotinamide nucleotide transhydrogenase
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRP1 neuropilin 1
OPHN1 oligophrenin 1
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
OXLD1 oxidoreductase-like domain containing 1
PAAF1 proteasomal ATPase-associated factor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP4 poly (ADP-ribose) polymerase family, member 4
PCYOX1L prenylcysteine oxidase 1 like
PDZRN3 PDZ domain containing ring finger 3
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PITX1 paired-like homeodomain 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLSCR3 phospholipid scramblase 3
PNKP polynucleotide kinase 3'-phosphatase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRAF2 PRA1 domain family, member 2
PRDX2 peroxiredoxin 2
PRKCD protein kinase C, delta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGES prostaglandin E synthase
PYGL phosphorylase, glycogen, liver
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAD51C RAD51 paralog C
RAD9A RAD9 homolog A (S. pombe)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBKS ribokinase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASEH2A ribonuclease H2, subunit A
RNASET2 ribonuclease T2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS5 ribosomal protein S5
S100A11 S100 calcium binding protein A11
S100B S100 calcium binding protein B
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SIGMAR1 sigma non-opioid intracellular receptor 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNF8 SNF8, ESCRT-II complex subunit
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORD sorbitol dehydrogenase
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPATA20 spermatogenesis associated 20
SRPX sushi-repeat containing protein, X-linked
SRSF1 serine/arginine-rich splicing factor 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK39 serine threonine kinase 39
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SVIL supervillin
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D16 TBC1 domain family, member 16
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
THTPA thiamine triphosphatase
TMEM2 transmembrane protein 2
TMEM5 transmembrane protein 5
TNC tenascin C
TNS3 tensin 3
TRIM44 tripartite motif containing 44
TRIOBP TRIO and F-actin binding protein
TRIP6 thyroid hormone receptor interactor 6
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VCAN versican
VWA8 von Willebrand factor A domain containing 8
WDR6 WD repeat domain 6
WFDC2 WAP four-disulfide core domain 2
ZBTB20 zinc finger and BTB domain containing 20