BRD-K84091085_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K84091085_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AEBP1 AE binding protein 1
ANXA6 annexin A6
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ATG3 autophagy related 3
BHLHE41 basic helix-loop-helix family, member e41
CCDC92 coiled-coil domain containing 92
CCND2 cyclin D2
CD200 CD200 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CXCL3 chemokine (C-X-C motif) ligand 3
DAPK1 death-associated protein kinase 1
DLK1 delta-like 1 homolog (Drosophila)
DNM1 dynamin 1
ERLIN2 ER lipid raft associated 2
GSTM3 glutathione S-transferase mu 3 (brain)
IGFBP5 insulin-like growth factor binding protein 5
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
MTUS1 microtubule associated tumor suppressor 1
MYO5C myosin VC
NBPF10 neuroblastoma breakpoint family, member 10
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDE4DIP phosphodiesterase 4D interacting protein
PEG3 paternally expressed 3
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNC1 plexin C1
PNMAL1 paraneoplastic Ma antigen family-like 1
PRNP prion protein
PROSC proline synthetase co-transcribed homolog (bacterial)
PTHLH parathyroid hormone-like hormone
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBBP8 retinoblastoma binding protein 8
RRAGD Ras-related GTP binding D
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC2 syndecan 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCEAL2 transcription elongation factor A (SII)-like 2
TIAM1 T-cell lymphoma invasion and metastasis 1
VIM vimentin

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMPD3 adenosine monophosphate deaminase 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BPIFA1 BPI fold containing family A, member 1
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLNS1A chloride channel, nucleotide-sensitive, 1A
CP ceruloplasmin (ferroxidase)
CXCL12 chemokine (C-X-C motif) ligand 12
EPAS1 endothelial PAS domain protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGG fibrinogen gamma chain
FMO2 flavin containing monooxygenase 2 (non-functional)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HGD homogentisate 1,2-dioxygenase
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
LAP3 leucine aminopeptidase 3
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1X metallothionein 1X
MYCBP MYC binding protein
NNMT nicotinamide N-methyltransferase
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QDPR quinoid dihydropteridine reductase
RHOB ras homolog family member B
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
STARD7 StAR-related lipid transfer (START) domain containing 7
TFPI2 tissue factor pathway inhibitor 2
TRIM22 tripartite motif containing 22
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1