BRD-K83972459_JWE-035_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K83972459_JWE-035_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
APLP2 amyloid beta (A4) precursor-like protein 2
BTG2 BTG family, member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL4A5 collagen, type IV, alpha 5
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHA2 EPH receptor A2
EPHB2 EPH receptor B2
FDXR ferredoxin reductase
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
ICAM1 intercellular adhesion molecule 1
IL6ST interleukin 6 signal transducer
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LRP10 low density lipoprotein receptor-related protein 10
MAP1B microtubule-associated protein 1B
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MYO6 myosin VI
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RPS27L ribosomal protein S27-like
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOMM34 translocase of outer mitochondrial membrane 34
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VGLL4 vestigial-like family member 4
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AK4 adenylate kinase 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALD1 caldesmon 1
CCL8 chemokine (C-C motif) ligand 8
CDK14 cyclin-dependent kinase 14
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFH complement factor H
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
DENND1B DENN/MADD domain containing 1B
DPT dermatopontin
DPYD dihydropyrimidine dehydrogenase
ESR1 estrogen receptor 1
FASTKD3 FAST kinase domains 3
GBP1 guanylate binding protein 1, interferon-inducible
GLUL glutamate-ammonia ligase
GTF3A general transcription factor IIIA
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOXC10 homeobox C10
HOXC6 homeobox C6
IFRD2 interferon-related developmental regulator 2
LGALS4 lectin, galactoside-binding, soluble, 4
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MMP2 matrix metallopeptidase 2
NRN1 neuritin 1
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDZK1 PDZ domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PRKCB protein kinase C, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNAI2 snail family zinc finger 2
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRIP13 thyroid hormone receptor interactor 13
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
ZMYM2 zinc finger, MYM-type 2