BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_SKM1_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_SKM1_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1C3 aldo-keto reductase family 1, member C3
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C1ORF115 chromosome 1 open reading frame 115
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DST dystonin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EIF1 eukaryotic translation initiation factor 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GATA3 GATA binding protein 3
GCLM glutamate-cysteine ligase, modifier subunit
GPER1 G protein-coupled estrogen receptor 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HYOU1 hypoxia up-regulated 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
ISG15 ISG15 ubiquitin-like modifier
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITM2A integral membrane protein 2A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOB monoamine oxidase B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLIN2 perilipin 2
PLSCR3 phospholipid scramblase 3
PROM1 prominin 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS4 regulator of G-protein signaling 4
S100A10 S100 calcium binding protein A10
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VEGFA vascular endothelial growth factor A
WIF1 WNT inhibitory factor 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BMP2 bone morphogenetic protein 2
CALCA calcitonin-related polypeptide alpha
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CXCL11 chemokine (C-X-C motif) ligand 11
DAAM1 dishevelled associated activator of morphogenesis 1
ECM1 extracellular matrix protein 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GLOD4 glyoxalase domain containing 4
GPM6A glycoprotein M6A
HES1 hes family bHLH transcription factor 1
HIST2H2BE histone cluster 2, H2be
IL1RN interleukin 1 receptor antagonist
KIF5C kinesin family member 5C
KRT4 keratin 4, type II
MAGEA3 melanoma antigen family A3
MMP12 matrix metallopeptidase 12
MREG melanoregulin
MSLN mesothelin
NRN1 neuritin 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PCP4 Purkinje cell protein 4
PFKP phosphofructokinase, platelet
S100P S100 calcium binding protein P
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
ZBTB18 zinc finger and BTB domain containing 18
ZNF185 zinc finger protein 185 (LIM domain)