BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMUGS_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMUGS_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
BAG3 BCL2-associated athanogene 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CACYBP calcyclin binding protein
CD163 CD163 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN10 claudin 10
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DOK5 docking protein 5
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GCH1 GTP cyclohydrolase 1
GCLM glutamate-cysteine ligase, modifier subunit
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
MSX1 msh homeobox 1
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NCK1 NCK adaptor protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RGS2 regulator of G-protein signaling 2
TMEM97 transmembrane protein 97
TSPAN8 tetraspanin 8
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CALD1 caldesmon 1
CD24 CD24 molecule
CES1 carboxylesterase 1
COL4A6 collagen, type IV, alpha 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FN1 fibronectin 1
FOXO3 forkhead box O3
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
INA internexin neuronal intermediate filament protein, alpha
INHBB inhibin, beta B
JAG1 jagged 1
KRT18 keratin 18, type I
LAMB1 laminin, beta 1
NAV2 neuron navigator 2
NBN nibrin
OLFM4 olfactomedin 4
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PNMAL1 paraneoplastic Ma antigen family-like 1
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
SDC2 syndecan 2
SFRP1 secreted frizzled-related protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOX4 SRY (sex determining region Y)-box 4
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TNS1 tensin 1
TNS3 tensin 3
TRIB3 tribbles pseudokinase 3