BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMGI_6.0_h_6.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMGI_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE1 adhesion G protein-coupled receptor E1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BASP1 brain abundant, membrane attached signal protein 1
CA12 carbonic anhydrase XII
CAST calpastatin
CD59 CD59 molecule, complement regulatory protein
CHMP4A charged multivesicular body protein 4A
CLIC4 chloride intracellular channel 4
COCH cochlin
CRYAB crystallin, alpha B
CYBA cytochrome b-245, alpha polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
FAM46A family with sequence similarity 46, member A
FLNB filamin B, beta
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
HOOK2 hook microtubule-tethering protein 2
HOXC6 homeobox C6
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
LMCD1 LIM and cysteine-rich domains 1
LTBP3 latent transforming growth factor beta binding protein 3
MAP7 microtubule-associated protein 7
NET1 neuroepithelial cell transforming 1
NPC2 Niemann-Pick disease, type C2
PCDH9 protocadherin 9
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTDSS1 phosphatidylserine synthase 1
PTER phosphotriesterase related
PTGDS prostaglandin D2 synthase 21kDa (brain)
PURA purine-rich element binding protein A
RABGAP1 RAB GTPase activating protein 1
RASA4 RAS p21 protein activator 4
RCAN1 regulator of calcineurin 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
UFM1 ubiquitin-fold modifier 1
XPO7 exportin 7

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AIM1 absent in melanoma 1
APOB apolipoprotein B
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL10A1 collagen, type X, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CX3CL1 chemokine (C-X3-C motif) ligand 1
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
DCHS1 dachsous cadherin-related 1
EDN1 endothelin 1
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM129A family with sequence similarity 129, member A
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FMO3 flavin containing monooxygenase 3
FRZB frizzled-related protein
FXYD6 FXYD domain containing ion transport regulator 6
GAGE3 G antigen 3
GAL galanin/GMAP prepropeptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LCN2 lipocalin 2
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
LY6H lymphocyte antigen 6 complex, locus H
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MEIS2 Meis homeobox 2
MEX3D mex-3 RNA binding family member D
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLVAP plasmalemma vesicle associated protein
PNMA2 paraneoplastic Ma antigen 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
RTN2 reticulon 2
SCG5 secretogranin V
SH3BGRL SH3 domain binding glutamate-rich protein like
SHOX2 short stature homeobox 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOX11 SRY (sex determining region Y)-box 11
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCF4 transcription factor 4
TFR2 transferrin receptor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TREM2 triggering receptor expressed on myeloid cells 2
TRIL TLR4 interactor with leucine-rich repeats
TUBB2A tubulin, beta 2A class IIa
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
ZEB1 zinc finger E-box binding homeobox 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF423 zinc finger protein 423