BRD-K83213911_PF 750_SKMEL28_6.0_h_80.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K83213911_PF 750_SKMEL28_6.0_h_80.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANKRD49 ankyrin repeat domain 49
ANXA3 annexin A3
AQP9 aquaporin 9
ATF3 activating transcription factor 3
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CEP57 centrosomal protein 57kDa
CNPY3 canopy FGF signaling regulator 3
COL6A2 collagen, type VI, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
FMO3 flavin containing monooxygenase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPR88 G protein-coupled receptor 88
HAPLN1 hyaluronan and proteoglycan link protein 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
MTMR2 myotubularin related protein 2
MX1 MX dynamin-like GTPase 1
NFIL3 nuclear factor, interleukin 3 regulated
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDE4DIP phosphodiesterase 4D interacting protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PROM1 prominin 1
PTCH1 patched 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFN stratifin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TF transferrin
THBS2 thrombospondin 2
TOB1 transducer of ERBB2, 1
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
ZBTB10 zinc finger and BTB domain containing 10
ZBTB18 zinc finger and BTB domain containing 18
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
ASPA aspartoacylase
C3 complement component 3
CA2 carbonic anhydrase II
CAST calpastatin
CBR3 carbonyl reductase 3
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CLCN3 chloride channel, voltage-sensitive 3
CLIC4 chloride intracellular channel 4
CTNND1 catenin (cadherin-associated protein), delta 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
ECH1 enoyl CoA hydratase 1, peroxisomal
ECM1 extracellular matrix protein 1
EMX2 empty spiracles homeobox 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESM1 endothelial cell-specific molecule 1
FABP4 fatty acid binding protein 4, adipocyte
GJA1 gap junction protein, alpha 1, 43kDa
IGF1 insulin-like growth factor 1 (somatomedin C)
LOX lysyl oxidase
MAP7 microtubule-associated protein 7
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NNMT nicotinamide N-methyltransferase
OSBPL1A oxysterol binding protein-like 1A
PODXL podocalyxin-like
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPRED2 sprouty-related, EVH1 domain containing 2
SPTSSA serine palmitoyltransferase, small subunit A
STAB1 stabilin 1
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSNL1 visinin-like 1