BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
AREG amphiregulin
BPHL biphenyl hydrolase-like (serine hydrolase)
C10ORF10 chromosome 10 open reading frame 10
CALD1 caldesmon 1
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERK ceramide kinase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FGFR2 fibroblast growth factor receptor 2
FST follistatin
GRAMD3 GRAM domain containing 3
GREM1 gremlin 1, DAN family BMP antagonist
HILPDA hypoxia inducible lipid droplet-associated
HSPA2 heat shock 70kDa protein 2
IGFBP3 insulin-like growth factor binding protein 3
IL1B interleukin 1, beta
INHBA inhibin, beta A
JAG1 jagged 1
KLF9 Kruppel-like factor 9
LAMA3 laminin, alpha 3
LPL lipoprotein lipase
MFAP5 microfibrillar associated protein 5
MUC16 mucin 16, cell surface associated
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLIN2 perilipin 2
PRSS23 protease, serine, 23
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFTPA2 surfactant protein A2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPBG trophoblast glycoprotein
TUBA1A tubulin, alpha 1a
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
CXCL13 chemokine (C-X-C motif) ligand 13
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
GATA2 GATA binding protein 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXA10 homeobox A10
HOXC6 homeobox C6
IL2RG interleukin 2 receptor, gamma
ITM2A integral membrane protein 2A
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LYZ lysozyme
NID2 nidogen 2 (osteonidogen)
NUP210 nucleoporin 210kDa
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRC1 protein regulator of cytokinesis 1
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
SOD2 superoxide dismutase 2, mitochondrial
TBC1D4 TBC1 domain family, member 4
UBE2S ubiquitin-conjugating enzyme E2S
XK X-linked Kx blood group