BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALB albumin
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CTTN cortactin
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FXYD2 FXYD domain containing ion transport regulator 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
KLF4 Kruppel-like factor 4 (gut)
LDOC1 leucine zipper, down-regulated in cancer 1
LMCD1 LIM and cysteine-rich domains 1
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAH phenylalanine hydroxylase
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRUNE2 prune homolog 2 (Drosophila)
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
RRAGD Ras-related GTP binding D
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SRSF6 serine/arginine-rich splicing factor 6
STC2 stanniocalcin 2
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176B transmembrane protein 176B
TRAF5 TNF receptor-associated factor 5
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1

decreased expression

Symbol Name
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
C2CD2 C2 calcium-dependent domain containing 2
C6ORF62 chromosome 6 open reading frame 62
CCDC86 coiled-coil domain containing 86
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DUSP22 dual specificity phosphatase 22
EGFL6 EGF-like-domain, multiple 6
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FASTKD5 FAST kinase domains 5
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
KANK1 KN motif and ankyrin repeat domains 1
KIF20A kinesin family member 20A
LASP1 LIM and SH3 protein 1
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MLEC malectin
NEFH neurofilament, heavy polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PBX3 pre-B-cell leukemia homeobox 3
PERP PERP, TP53 apoptosis effector
PSIP1 PC4 and SFRS1 interacting protein 1
RAB4A RAB4A, member RAS oncogene family
SFRP4 secreted frizzled-related protein 4
SPON1 spondin 1, extracellular matrix protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
UBE3C ubiquitin protein ligase E3C