BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
C6ORF48 chromosome 6 open reading frame 48
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CD81 CD81 molecule
CDR2L cerebellar degeneration-related protein 2-like
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GRB10 growth factor receptor-bound protein 10
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBEGF heparin-binding EGF-like growth factor
HNMT histamine N-methyltransferase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGKV3-20 immunoglobulin kappa variable 3-20
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2A integral membrane protein 2A
KLF6 Kruppel-like factor 6
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
MOK MOK protein kinase
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PDZD2 PDZ domain containing 2
PEBP1 phosphatidylethanolamine binding protein 1
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
PYGL phosphorylase, glycogen, liver
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TAGLN transgelin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TPM1 tropomyosin 1 (alpha)
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADGRL1 adhesion G protein-coupled receptor L1
ASCL1 achaete-scute family bHLH transcription factor 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCND3 cyclin D3
CCNF cyclin F
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DPP4 dipeptidyl-peptidase 4
EMP2 epithelial membrane protein 2
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HES1 hes family bHLH transcription factor 1
KIF20A kinesin family member 20A
LPCAT1 lysophosphatidylcholine acyltransferase 1
MDFIC MyoD family inhibitor domain containing
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
OLFM1 olfactomedin 1
OSBPL10 oxysterol binding protein-like 10
PDE4B phosphodiesterase 4B, cAMP-specific
PERP PERP, TP53 apoptosis effector
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM1 ribonucleotide reductase M1
SCGB1D2 secretoglobin, family 1D, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFTPA2 surfactant protein A2
SPTSSA serine palmitoyltransferase, small subunit A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
VCAN versican
WIF1 WNT inhibitory factor 1