BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K83194053_4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol CU-00000000029-2_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP6 acid phosphatase 6, lysophosphatidic
ADIRF adipogenesis regulatory factor
ALB albumin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
C3ORF14 chromosome 3 open reading frame 14
C8ORF4 chromosome 8 open reading frame 4
CD24 CD24 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN3 claudin 3
CPA3 carboxypeptidase A3 (mast cell)
CTAG2 cancer/testis antigen 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP22 dual specificity phosphatase 22
ESR1 estrogen receptor 1
FBXL12 F-box and leucine-rich repeat protein 12
FST follistatin
GPC3 glypican 3
ICAM2 intercellular adhesion molecule 2
IGFBP3 insulin-like growth factor binding protein 3
KRT23 keratin 23, type I
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA4 melanoma antigen family A4
MLPH melanophilin
MTA1 metastasis associated 1
MUC16 mucin 16, cell surface associated
NEBL nebulette
NPTX2 neuronal pentraxin II
PCCB propionyl CoA carboxylase, beta polypeptide
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG3 paternally expressed 3
PRSS23 protease, serine, 23
PTPRK protein tyrosine phosphatase, receptor type, K
RBP1 retinol binding protein 1, cellular
S100P S100 calcium binding protein P
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAGLN transgelin
TBX3 T-box 3
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPRSS3 transmembrane protease, serine 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACTB actin, beta
ADGRG1 adhesion G protein-coupled receptor G1
ANKRD10 ankyrin repeat domain 10
CA2 carbonic anhydrase II
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A5 collagen, type IV, alpha 5
CST3 cystatin C
CYCS cytochrome c, somatic
DSE dermatan sulfate epimerase
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM3C family with sequence similarity 3, member C
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
HBB hemoglobin, beta
HMGB3 high mobility group box 3
HSPB8 heat shock 22kDa protein 8
IGFBP5 insulin-like growth factor binding protein 5
JADE2 jade family PHD finger 2
KRT18 keratin 18, type I
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
MDFIC MyoD family inhibitor domain containing
MKI67 marker of proliferation Ki-67
PITX1 paired-like homeodomain 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PPARD peroxisome proliferator-activated receptor delta
PRDX1 peroxiredoxin 1
PRKCD protein kinase C, delta
S100A2 S100 calcium binding protein A2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC43A3 solute carrier family 43, member 3
SORBS1 sorbin and SH3 domain containing 1
STEAP3 STEAP family member 3, metalloreductase
TGM2 transglutaminase 2
TPX2 TPX2, microtubule-associated