BRD-K82928847_rocilinostat_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K82928847_rocilinostat_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BACE2 beta-site APP-cleaving enzyme 2
C8ORF4 chromosome 8 open reading frame 4
CD47 CD47 molecule
CD69 CD69 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLU clusterin
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
ECI2 enoyl-CoA delta isomerase 2
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
F2RL1 coagulation factor II (thrombin) receptor-like 1
GRN granulin
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGHM immunoglobulin heavy constant mu
KLF6 Kruppel-like factor 6
MAMLD1 mastermind-like domain containing 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSX1 msh homeobox 1
NOV nephroblastoma overexpressed
NREP neuronal regeneration related protein
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PLAGL1 pleiomorphic adenoma gene-like 1
PSAP prosaposin
PTN pleiotrophin
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHOB ras homolog family member B
RPS11 ribosomal protein S11
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SOX4 SRY (sex determining region Y)-box 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMSB15A thymosin beta 15a
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UBE2E1 ubiquitin-conjugating enzyme E2E 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADI1 acireductone dioxygenase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
AUTS2 autism susceptibility candidate 2
CCL5 chemokine (C-C motif) ligand 5
CDK14 cyclin-dependent kinase 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTSB cathepsin B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GSAP gamma-secretase activating protein
HOPX HOP homeobox
HOXC10 homeobox C10
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
LMO4 LIM domain only 4
MSRA methionine sulfoxide reductase A
MUC1 mucin 1, cell surface associated
NEFM neurofilament, medium polypeptide
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
POSTN periostin, osteoblast specific factor
RPS4Y1 ribosomal protein S4, Y-linked 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
THBS2 thrombospondin 2
TLK2 tousled-like kinase 2
TP63 tumor protein p63
ZMYM2 zinc finger, MYM-type 2
ZNF512B zinc finger protein 512B