BRD-K82823804_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K82823804_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGRE5 adhesion G protein-coupled receptor E5
ADM adrenomedullin
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BACE2 beta-site APP-cleaving enzyme 2
BCL10 B-cell CLL/lymphoma 10
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C5AR1 complement component 5a receptor 1
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CXORF40B chromosome X open reading frame 40B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HCAR3 hydroxycarboxylic acid receptor 3
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INPP1 inositol polyphosphate-1-phosphatase
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LOX lysyl oxidase
LRP10 low density lipoprotein receptor-related protein 10
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM4 PDZ and LIM domain 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAB31 RAB31, member RAS oncogene family
RBPMS RNA binding protein with multiple splicing
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSU1 Ras suppressor protein 1
RTN2 reticulon 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TANK TRAF family member-associated NFKB activator
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TIGAR TP53 induced glycolysis regulatory phosphatase
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
TSPO translocator protein (18kDa)
TUBB6 tubulin, beta 6 class V
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AUTS2 autism susceptibility candidate 2
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC4 chloride intracellular channel 4
CLTC clathrin, heavy chain (Hc)
COX11 COX11 cytochrome c oxidase copper chaperone
CXCL12 chemokine (C-X-C motif) ligand 12
DCN decorin
FABP7 fatty acid binding protein 7, brain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNAS GNAS complex locus
IFRD2 interferon-related developmental regulator 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KRT19 keratin 19, type I
KRT8 keratin 8, type II
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MEF2C myocyte enhancer factor 2C
MXRA7 matrix-remodelling associated 7
NEBL nebulette
PEG3 paternally expressed 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
POU2AF1 POU class 2 associating factor 1
PRMT1 protein arginine methyltransferase 1
PROM1 prominin 1
RHOBTB3 Rho-related BTB domain containing 3
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SOBP sine oculis binding protein homolog (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRSF1 serine/arginine-rich splicing factor 1
SRSF7 serine/arginine-rich splicing factor 7
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
VCAN versican