BRD-K82732294_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K82732294_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF62 chromosome 6 open reading frame 62
CALML3 calmodulin-like 3
CAPN2 calpain 2, (m/II) large subunit
CDKN2A cyclin-dependent kinase inhibitor 2A
CHIC2 cysteine-rich hydrophobic domain 2
CRYAB crystallin, alpha B
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSG3 desmoglein 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP22 dual specificity phosphatase 22
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FTH1 ferritin, heavy polypeptide 1
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGF1R insulin-like growth factor 1 receptor
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTSS1 metastasis suppressor 1
MX2 MX dynamin-like GTPase 2
NDRG1 N-myc downstream regulated 1
NPC1 Niemann-Pick disease, type C1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKP1 plakophilin 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RCAN1 regulator of calcineurin 1
REEP5 receptor accessory protein 5
RHOB ras homolog family member B
RIOK3 RIO kinase 3
SAMD9 sterile alpha motif domain containing 9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TP63 tumor protein p63
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
ZEB2 zinc finger E-box binding homeobox 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNF cyclin F
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FRZB frizzled-related protein
GINS1 GINS complex subunit 1 (Psf1 homolog)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCAM melanoma cell adhesion molecule
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
MMD monocyte to macrophage differentiation-associated
MUC16 mucin 16, cell surface associated
MXRA5 matrix-remodelling associated 5
MYH10 myosin, heavy chain 10, non-muscle
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
NISCH nischarin
NPR1 natriuretic peptide receptor 1
PLAGL1 pleiomorphic adenoma gene-like 1
PNMA2 paraneoplastic Ma antigen 2
PNMAL1 paraneoplastic Ma antigen family-like 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PRUNE2 prune homolog 2 (Drosophila)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
REEP1 receptor accessory protein 1
RNF167 ring finger protein 167
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TCF4 transcription factor 4
TNS1 tensin 1
UPK1B uroplakin 1B