BRD-K82357231_8-chloro-11-piperidin-4-ylidene-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridine_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K82357231_8-chloro-11-piperidin-4-ylidene-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridine_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM12 ADAM metallopeptidase domain 12
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CADPS2 Ca++-dependent secretion activator 2
COL11A1 collagen, type XI, alpha 1
CSRP1 cysteine and glycine-rich protein 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHDDS dehydrodolichyl diphosphate synthase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXC6 homeobox C6
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PRSS23 protease, serine, 23
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP1 syntaxin binding protein 1
TRIB1 tribbles pseudokinase 1
TSPAN13 tetraspanin 13
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CP ceruloplasmin (ferroxidase)
CTNND1 catenin (cadherin-associated protein), delta 1
EDN1 endothelin 1
FOXF2 forkhead box F2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
NR2F6 nuclear receptor subfamily 2, group F, member 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
RGS5 regulator of G-protein signaling 5
RNASET2 ribonuclease T2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
TGM2 transglutaminase 2
TMEM176B transmembrane protein 176B
ZEB1 zinc finger E-box binding homeobox 1