BRD-K81876028_CP 93129 dihydrochloride_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K81876028_CP 93129 dihydrochloride_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
AIM1 absent in melanoma 1
ARMCX1 armadillo repeat containing, X-linked 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CA4 carbonic anhydrase IV
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD200 CD200 molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLEC2B C-type lectin domain family 2, member B
COG7 component of oligomeric golgi complex 7
COL4A6 collagen, type IV, alpha 6
CRABP2 cellular retinoic acid binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPYD dihydropyrimidine dehydrogenase
EDN1 endothelin 1
ESM1 endothelial cell-specific molecule 1
EXT1 exostosin glycosyltransferase 1
FAM198B family with sequence similarity 198, member B
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRB7 growth factor receptor-bound protein 7
GSDMB gasdermin B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HPGDS hematopoietic prostaglandin D synthase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
ISOC1 isochorismatase domain containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
LDOC1 leucine zipper, down-regulated in cancer 1
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LY96 lymphocyte antigen 96
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MTERF3 mitochondrial transcription termination factor 3
MX1 MX dynamin-like GTPase 1
NEFH neurofilament, heavy polypeptide
NOX4 NADPH oxidase 4
NPIPB3 nuclear pore complex interacting protein family, member B3
NRP1 neuropilin 1
NXN nucleoredoxin
P3H2 prolyl 3-hydroxylase 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
RAI14 retinoic acid induced 14
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHB Src homology 2 domain containing adaptor protein B
SLC38A2 solute carrier family 38, member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPON2 spondin 2, extracellular matrix protein
SRGN serglycin
SSBP2 single-stranded DNA binding protein 2
STON1 stonin 1
TCTA T-cell leukemia translocation altered
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
THBS2 thrombospondin 2
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM35 transmembrane protein 35
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TPM4 tropomyosin 4
TRIM22 tripartite motif containing 22
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
ZEB1 zinc finger E-box binding homeobox 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331
ZNF586 zinc finger protein 586
ZNF83 zinc finger protein 83
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
AGR2 anterior gradient 2
APLP2 amyloid beta (A4) precursor-like protein 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C16ORF45 chromosome 16 open reading frame 45
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
CFH complement factor H
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GMDS GDP-mannose 4,6-dehydratase
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXC6 homeobox C6
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF1R insulin-like growth factor 1 receptor
IQCG IQ motif containing G
KDSR 3-ketodihydrosphingosine reductase
KRT7 keratin 7, type II
MAB21L2 mab-21-like 2 (C. elegans)
MCOLN1 mucolipin 1
MFSD10 major facilitator superfamily domain containing 10
MLF1 myeloid leukemia factor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPC2 Niemann-Pick disease, type C2
NUTF2 nuclear transport factor 2
OLFML2B olfactomedin-like 2B
PCDH9 protocadherin 9
PLTP phospholipid transfer protein
PPIF peptidylprolyl isomerase F
PPIG peptidylprolyl isomerase G (cyclophilin G)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX1 peroxiredoxin 1
PSD3 pleckstrin and Sec7 domain containing 3
PTER phosphotriesterase related
PTGES prostaglandin E synthase
RRAGD Ras-related GTP binding D
S100A11 S100 calcium binding protein A11
SECISBP2L SECIS binding protein 2-like
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPEN spen family transcriptional repressor
SRP54 signal recognition particle 54kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TOB1 transducer of ERBB2, 1
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
YBX3 Y box binding protein 3