BRD-K81538844_6-(2-Fluoro-benzyl)-2,4-dimethyl-4,6-dihydro-thieno[2,3:4,5]pyrrolo[2,3-d]pyridazin-5-one_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K81538844_6-(2-Fluoro-benzyl)-2,4-dimethyl-4,6-dihydro-thieno[2,3:4,5]pyrrolo[2,3-d]pyridazin-5-one_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ALOX5 arachidonate 5-lipoxygenase
ANGPT2 angiopoietin 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BCL6 B-cell CLL/lymphoma 6
CAST calpastatin
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRDL1 chordin-like 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM69A family with sequence similarity 69, member A
G0S2 G0/G1 switch 2
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H2BD histone cluster 1, H2bd
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
JCHAIN joining chain of multimeric IgA and IgM
KCNK3 potassium channel, two pore domain subfamily K, member 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO3 LIM domain only 3 (rhombotin-like 2)
LTB lymphotoxin beta (TNF superfamily, member 3)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MMP10 matrix metallopeptidase 10
MUC2 mucin 2, oligomeric mucus/gel-forming
NEFH neurofilament, heavy polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRCAM neuronal cell adhesion molecule
OGN osteoglycin
PAGE4 P antigen family, member 4 (prostate associated)
PDZD2 PDZ domain containing 2
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PNMA2 paraneoplastic Ma antigen 2
PPOX protoporphyrinogen oxidase
PRKCI protein kinase C, iota
PRUNE2 prune homolog 2 (Drosophila)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSPH phosphoserine phosphatase
PVALB parvalbumin
PXDN peroxidasin
RAD51AP1 RAD51 associated protein 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
TFRC transferrin receptor
TUBA4A tubulin, alpha 4a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARF4 ADP-ribosylation factor 4
ATXN1 ataxin 1
BCLAF1 BCL2-associated transcription factor 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COLEC12 collectin sub-family member 12
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
EGR3 early growth response 3
ERLIN1 ER lipid raft associated 1
FAM198B family with sequence similarity 198, member B
FZD7 frizzled class receptor 7
GPRC5A G protein-coupled receptor, class C, group 5, member A
GREM1 gremlin 1, DAN family BMP antagonist
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA1 interleukin 13 receptor, alpha 1
LAMP1 lysosomal-associated membrane protein 1
LY6D lymphocyte antigen 6 complex, locus D
LYST lysosomal trafficking regulator
MGP matrix Gla protein
NCOA4 nuclear receptor coactivator 4
RAB14 RAB14, member RAS oncogene family
RANBP2 RAN binding protein 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SORD sorbitol dehydrogenase
STAT1 signal transducer and activator of transcription 1, 91kDa
SYPL1 synaptophysin-like 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
VAT1 vesicle amine transport 1
WDR1 WD repeat domain 1
XAF1 XIAP associated factor 1
ZNF586 zinc finger protein 586