BRD-K81528515_nilotinib_SKBR3_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K81528515_nilotinib_SKBR3_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA12 carbonic anhydrase XII
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EGR3 early growth response 3
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CADM1 cell adhesion molecule 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GUSBP3 glucuronidase, beta pseudogene 3
LYZ lysozyme
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PIP prolactin-induced protein
RELN reelin
RGCC regulator of cell cycle
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
TAGLN transgelin
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TSEN2 TSEN2 tRNA splicing endonuclease subunit