BRD-K81528515_nilotinib_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K81528515_nilotinib_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK AHNAK nucleoprotein
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
F12 coagulation factor XII (Hageman factor)
FAM60A family with sequence similarity 60, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
H1F0 H1 histone family, member 0
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL32 interleukin 32
KIAA0753 KIAA0753
KRT13 keratin 13, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LY75 lymphocyte antigen 75
MMP7 matrix metallopeptidase 7
OLFM4 olfactomedin 4
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDZK1IP1 PDZK1 interacting protein 1
PON2 paraoxonase 2
POU2AF1 POU class 2 associating factor 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AHR aryl hydrocarbon receptor
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPN1 calpain 1, (mu/I) large subunit
CD36 CD36 molecule (thrombospondin receptor)
CLGN calmegin
COL5A1 collagen, type V, alpha 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
FABP4 fatty acid binding protein 4, adipocyte
FLG filaggrin
FPR1 formyl peptide receptor 1
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BK histone cluster 1, H2bk
HNMT histamine N-methyltransferase
HTRA1 HtrA serine peptidase 1
INHBB inhibin, beta B
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LOX lysyl oxidase
LXN latexin
MSMO1 methylsterol monooxygenase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
POSTN periostin, osteoblast specific factor
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS4 regulator of G-protein signaling 4
S100A2 S100 calcium binding protein A2
SCGB2A2 secretoglobin, family 2A, member 2
SKAP2 src kinase associated phosphoprotein 2
SLIT2 slit homolog 2 (Drosophila)
SPARCL1 SPARC-like 1 (hevin)
TES testin LIM domain protein
VCAN versican
XBP1 X-box binding protein 1
ZNF91 zinc finger protein 91