BRD-K81528515_nilotinib_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K81528515_nilotinib_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ASPH aspartate beta-hydroxylase
BCHE butyrylcholinesterase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD44 CD44 molecule (Indian blood group)
CHN1 chimerin 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FOSL1 FOS-like antigen 1
FXYD5 FXYD domain containing ion transport regulator 5
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
HDAC9 histone deacetylase 9
LOC100505650 uncharacterized LOC100505650
LTF lactotransferrin
MBP myelin basic protein
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
NRN1 neuritin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASET2 ribonuclease T2
SCG5 secretogranin V
SLPI secretory leukocyte peptidase inhibitor
STC1 stanniocalcin 1
SVIL supervillin
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TUBB6 tubulin, beta 6 class V
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BHLHE40 basic helix-loop-helix family, member e40
C9ORF3 chromosome 9 open reading frame 3
CD52 CD52 molecule
CD69 CD69 molecule
CLIC3 chloride intracellular channel 3
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAAM1 dishevelled associated activator of morphogenesis 1
DHCR7 7-dehydrocholesterol reductase
EFHD1 EF-hand domain family, member D1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
INSIG1 insulin induced gene 1
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LDLR low density lipoprotein receptor
LMCD1 LIM and cysteine-rich domains 1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
NNMT nicotinamide N-methyltransferase
PAWR PRKC, apoptosis, WT1, regulator
PBX3 pre-B-cell leukemia homeobox 3
POSTN periostin, osteoblast specific factor
RGS1 regulator of G-protein signaling 1
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SULF1 sulfatase 1
TFRC transferrin receptor
TOX3 TOX high mobility group box family member 3
XIST X inactive specific transcript (non-protein coding)