BRD-K81528515_nilotinib_A549_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-K81528515_nilotinib_A549_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG2 adhesion G protein-coupled receptor G2
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
ALCAM activated leukocyte cell adhesion molecule
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
C1S complement component 1, s subcomponent
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CHRDL1 chordin-like 1
COL4A2 collagen, type IV, alpha 2
DUSP4 dual specificity phosphatase 4
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
ERGIC3 ERGIC and golgi 3
F2R coagulation factor II (thrombin) receptor
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
GALC galactosylceramidase
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
GUSB glucuronidase, beta
HEBP1 heme binding protein 1
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LTA4H leukotriene A4 hydrolase
MARCKSL1 MARCKS-like 1
MDK midkine (neurite growth-promoting factor 2)
MSLN mesothelin
MTMR11 myotubularin related protein 11
MXRA7 matrix-remodelling associated 7
MYOF myoferlin
MYRF myelin regulatory factor
MZT2A mitotic spindle organizing protein 2A
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NMU neuromedin U
NPEPL1 aminopeptidase-like 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PLSCR4 phospholipid scramblase 4
PODXL podocalyxin-like
RBKS ribokinase
RBM47 RNA binding motif protein 47
RBP1 retinol binding protein 1, cellular
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCEA2 transcription elongation factor A (SII), 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TNNT1 troponin T type 1 (skeletal, slow)
TRAPPC6A trafficking protein particle complex 6A
TST thiosulfate sulfurtransferase (rhodanese)
UGDH UDP-glucose 6-dehydrogenase
VAT1 vesicle amine transport 1
VCAN versican
VEGFC vascular endothelial growth factor C
VWF von Willebrand factor
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACP5 acid phosphatase 5, tartrate resistant
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
CALML3 calmodulin-like 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
CTSZ cathepsin Z
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FBP1 fructose-1,6-bisphosphatase 1
FKBP14 FK506 binding protein 14, 22 kDa
GARS glycyl-tRNA synthetase
GCH1 GTP cyclohydrolase 1
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GPM6B glycoprotein M6B
HOXC10 homeobox C10
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
IRX5 iroquois homeobox 5
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LEF1 lymphoid enhancer-binding factor 1
LINC00341 long intergenic non-protein coding RNA 341
LMO4 LIM domain only 4
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MARS methionyl-tRNA synthetase
MMP12 matrix metallopeptidase 12
NGRN neugrin, neurite outgrowth associated
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
RCAN1 regulator of calcineurin 1
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRR1A small proline-rich protein 1A
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TNC tenascin C
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
VLDLR very low density lipoprotein receptor
WIF1 WNT inhibitory factor 1