BRD-K81418486_vorinostat_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K81418486_vorinostat_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ANO10 anoctamin 10
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BEX1 brain expressed, X-linked 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
CCNE2 cyclin E2
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CTSC cathepsin C
DHRS7 dehydrogenase/reductase (SDR family) member 7
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EREG epiregulin
EYA1 EYA transcriptional coactivator and phosphatase 1
FGG fibrinogen gamma chain
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEBP1 heme binding protein 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HOXA5 homeobox A5
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
IFITM2 interferon induced transmembrane protein 2
JARID2 jumonji, AT rich interactive domain 2
KLK6 kallikrein-related peptidase 6
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LRRC17 leucine rich repeat containing 17
MEIS1 Meis homeobox 1
METRN meteorin, glial cell differentiation regulator
MITF microphthalmia-associated transcription factor
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MXI1 MAX interactor 1, dimerization protein
NAMPT nicotinamide phosphoribosyltransferase
NEFL neurofilament, light polypeptide
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OPN3 opsin 3
OSR2 odd-skipped related transciption factor 2
PBX1 pre-B-cell leukemia homeobox 1
PCDH7 protocadherin 7
PCSK1 proprotein convertase subtilisin/kexin type 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
RTN2 reticulon 2
S100A7 S100 calcium binding protein A7
SCG2 secretogranin II
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGCE sarcoglycan, epsilon
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRGN serglycin
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN2 stathmin 2
STOM stomatin
TAC1 tachykinin, precursor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TMOD1 tropomodulin 1
TPBG trophoblast glycoprotein
TROVE2 TROVE domain family, member 2
TSPAN13 tetraspanin 13
VAT1 vesicle amine transport 1
VCAN versican
VWA5A von Willebrand factor A domain containing 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACYP2 acylphosphatase 2, muscle type
ADI1 acireductone dioxygenase 1
AGA aspartylglucosaminidase
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CD9 CD9 molecule
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFS embryonal Fyn-associated substrate
EGF epidermal growth factor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM129A family with sequence similarity 129, member A
FBP1 fructose-1,6-bisphosphatase 1
FGFR3 fibroblast growth factor receptor 3
GAS2L1 growth arrest-specific 2 like 1
GBP1 guanylate binding protein 1, interferon-inducible
GSAP gamma-secretase activating protein
GSTT1 glutathione S-transferase theta 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBB hemoglobin, beta
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IL1RN interleukin 1 receptor antagonist
ISG20 interferon stimulated exonuclease gene 20kDa
JUP junction plakoglobin
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KLK11 kallikrein-related peptidase 11
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARC1 mitochondrial amidoxime reducing component 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MMP3 matrix metallopeptidase 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
PLBD1 phospholipase B domain containing 1
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PTS 6-pyruvoyltetrahydropterin synthase
PTX3 pentraxin 3, long
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCCPDH saccharopine dehydrogenase (putative)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX7 sorting nexin 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TFF3 trefoil factor 3 (intestinal)
THY1 Thy-1 cell surface antigen