BRD-K81418486_vorinostat_CORL23_6.0_h_11.1_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

219 genes differentially expressed following the BRD-K81418486_vorinostat_CORL23_6.0_h_11.1_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASRGL1 asparaginase like 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BLVRA biliverdin reductase A
BLVRB biliverdin reductase B
C14ORF132 chromosome 14 open reading frame 132
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCA1 chloride channel accessory 1
CLDN3 claudin 3
CLPTM1 cleft lip and palate associated transmembrane protein 1
CPM carboxypeptidase M
CTSH cathepsin H
CYB5R1 cytochrome b5 reductase 1
CYBB cytochrome b-245, beta polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS3 fatty acid desaturase 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSDMB gasdermin B
HEBP1 heme binding protein 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI6 interferon, alpha-inducible protein 6
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IQGAP2 IQ motif containing GTPase activating protein 2
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LGMN legumain
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MID1 midline 1
MLF1 myeloid leukemia factor 1
MPC1 mitochondrial pyruvate carrier 1
MTMR11 myotubularin related protein 11
MYH10 myosin, heavy chain 10, non-muscle
NEBL nebulette
NMU neuromedin U
NOSIP nitric oxide synthase interacting protein
NPC2 Niemann-Pick disease, type C2
NPY neuropeptide Y
NR2F1 nuclear receptor subfamily 2, group F, member 1
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PDE9A phosphodiesterase 9A
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLS1 plastin 1
PNMA2 paraneoplastic Ma antigen 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRE protein tyrosine phosphatase, receptor type, E
RAP1GAP RAP1 GTPase activating protein
RIMS3 regulating synaptic membrane exocytosis 3
RNASET2 ribonuclease T2
ROGDI rogdi homolog (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCPEP1 serine carboxypeptidase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNN stannin
SPINK4 serine peptidase inhibitor, Kazal type 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK17A serine/threonine kinase 17a
STX7 syntaxin 7
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBPL1 TBP-like 1
TBX3 T-box 3
TCL1A T-cell leukemia/lymphoma 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPPP3 tubulin polymerization-promoting protein family member 3
TUBB2A tubulin, beta 2A class IIa
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF5 activating transcription factor 5
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
CADM1 cell adhesion molecule 1
CALML3 calmodulin-like 3
CCND1 cyclin D1
CCND2 cyclin D2
COL15A1 collagen, type XV, alpha 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EIF5 eukaryotic translation initiation factor 5
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FGFBP1 fibroblast growth factor binding protein 1
FHL2 four and a half LIM domains 2
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
FST follistatin
GABPB1 GA binding protein transcription factor, beta subunit 1
GAL galanin/GMAP prepropeptide
GAS2 growth arrest-specific 2
GRWD1 glutamate-rich WD repeat containing 1
HMGA2 high mobility group AT-hook 2
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0368 KIAA0368
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LCN2 lipocalin 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM7 minichromosome maintenance complex component 7
MFAP5 microfibrillar associated protein 5
MRPS30 mitochondrial ribosomal protein S30
NBN nibrin
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
OBSL1 obscurin-like 1
PDGFC platelet derived growth factor C
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTHLH parathyroid hormone-like hormone
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB13 RAB13, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC35F2 solute carrier family 35, member F2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMYD2 SET and MYND domain containing 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
UPK1B uroplakin 1B
USP22 ubiquitin specific peptidase 22
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF652 zinc finger protein 652