BRD-K80348542_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K80348542_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BEX1 brain expressed, X-linked 1
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CNN3 calponin 3, acidic
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL2 chemokine (C-X-C motif) ligand 2
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FAM179B family with sequence similarity 179, member B
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
KRT15 keratin 15, type I
LOC100272216 uncharacterized LOC100272216
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPD1 LY6/PLAUR domain containing 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDE9A phosphodiesterase 9A
PER2 period circadian clock 2
PLCB4 phospholipase C, beta 4
PTBP2 polypyrimidine tract binding protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RND3 Rho family GTPase 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TF transferrin
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIO trio Rho guanine nucleotide exchange factor
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
AKR1C3 aldo-keto reductase family 1, member C3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
B3GNT1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD99 CD99 molecule
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
FAM57A family with sequence similarity 57, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREM1 gremlin 1, DAN family BMP antagonist
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM2 interferon induced transmembrane protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0100 KIAA0100
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MLEC malectin
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
PEBP1 phosphatidylethanolamine binding protein 1
PGK1 phosphoglycerate kinase 1
POSTN periostin, osteoblast specific factor
PRDX4 peroxiredoxin 4
PXMP2 peroxisomal membrane protein 2, 22kDa
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
TFRC transferrin receptor
TKT transketolase
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM97 transmembrane protein 97
TUBB tubulin, beta class I
VAT1 vesicle amine transport 1