BRD-K79404599_enzastaurin_MDAMB231_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K79404599_enzastaurin_MDAMB231_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP2A3 ATPase, Ca++ transporting, ubiquitous
CALR calreticulin
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFI complement factor I
CHMP6 charged multivesicular body protein 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAM134B family with sequence similarity 134, member B
FAS Fas cell surface death receptor
FASN fatty acid synthase
FUCA1 fucosidase, alpha-L- 1, tissue
GLS glutaminase
GNAS GNAS complex locus
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSPA2 heat shock 70kDa protein 2
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
INSIG1 insulin induced gene 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LOC100505650 uncharacterized LOC100505650
MYH10 myosin, heavy chain 10, non-muscle
PON3 paraoxonase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RHOBTB1 Rho-related BTB domain containing 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
WFDC2 WAP four-disulfide core domain 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BTG1 B-cell translocation gene 1, anti-proliferative
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CFD complement factor D (adipsin)
CTGF connective tissue growth factor
EMP1 epithelial membrane protein 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
FOXD1 forkhead box D1
FSTL1 follistatin-like 1
GPM6B glycoprotein M6B
IL7R interleukin 7 receptor
KLF9 Kruppel-like factor 9
KYNU kynureninase
LPL lipoprotein lipase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYH11 myosin, heavy chain 11, smooth muscle
NGRN neugrin, neurite outgrowth associated
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
SFRP1 secreted frizzled-related protein 1
SMAD3 SMAD family member 3
SRGN serglycin
THBD thrombomodulin
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPBG trophoblast glycoprotein
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
UGCG UDP-glucose ceramide glucosyltransferase
XCL1 chemokine (C motif) ligand 1