BRD-K79259477_KIN001-265_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K79259477_KIN001-265_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ANXA3 annexin A3
ANXA9 annexin A9
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX6 armadillo repeat containing, X-linked 6
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BTG2 BTG family, member 2
C1QB complement component 1, q subcomponent, B chain
CCNG2 cyclin G2
CD47 CD47 molecule
CLIC3 chloride intracellular channel 3
COL1A2 collagen, type I, alpha 2
CRYAB crystallin, alpha B
CYBA cytochrome b-245, alpha polypeptide
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FTH1 ferritin, heavy polypeptide 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX1 glutathione peroxidase 1
GPX4 glutathione peroxidase 4
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMG20B high mobility group 20B
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
KRT20 keratin 20, type I
LUM lumican
LY96 lymphocyte antigen 96
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MXRA7 matrix-remodelling associated 7
NCAM1 neural cell adhesion molecule 1
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NEB nebulin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NNT nicotinamide nucleotide transhydrogenase
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
ORAI3 ORAI calcium release-activated calcium modulator 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHYH phytanoyl-CoA 2-hydroxylase
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRAF2 PRA1 domain family, member 2
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
VAT1 vesicle amine transport 1
ZNF274 zinc finger protein 274
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
AQP3 aquaporin 3 (Gill blood group)
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEMIP cell migration inducing protein, hyaluronan binding
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
ELANE elastase, neutrophil expressed
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EXOSC4 exosome component 4
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPH1 heat shock 105kDa/110kDa protein 1
IER3 immediate early response 3
INHBA inhibin, beta A
KCTD12 potassium channel tetramerization domain containing 12
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1B myosin IB
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SQRDL sulfide quinone reductase-like (yeast)
STX1A syntaxin 1A (brain)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor